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A selective p53 activator and anticancer agent to improve colorectal cancer therapy.
Ramos H, Soares MIL, Silva J, Raimundo L, Calheiros J, Gomes C, Reis F, Monteiro FA, Nunes C, Reis S, Bosco B, Piazza S, Domingues L, Chlapek P, Vlcek P, Fabian P, Rajado AT, Carvalho ATP, Veselska R, Inga A, Pinho E Melo TMVD, Saraiva L. Ramos H, et al. Among authors: domingues l. Cell Rep. 2021 Apr 13;35(2):108982. doi: 10.1016/j.celrep.2021.108982. Cell Rep. 2021. PMID: 33852837 Free article.
SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
Gomes S, Bosco B, Loureiro JB, Ramos H, Raimundo L, Soares J, Nazareth N, Barcherini V, Domingues L, Oliveira C, Bisio A, Piazza S, Bauer MR, Brás JP, Almeida MI, Gomes C, Reis F, Fersht AR, Inga A, Santos MMM, Saraiva L. Gomes S, et al. Among authors: domingues l. Cancers (Basel). 2019 Aug 10;11(8):1151. doi: 10.3390/cancers11081151. Cancers (Basel). 2019. PMID: 31405179 Free PMC article.
SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations.
Gomes AS, Ramos H, Gomes S, Loureiro JB, Soares J, Barcherini V, Monti P, Fronza G, Oliveira C, Domingues L, Bastos M, Dourado DFAR, Carvalho AL, Romão MJ, Pinheiro B, Marcelo F, Carvalho A, Santos MMM, Saraiva L. Gomes AS, et al. Among authors: domingues l. Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129440. doi: 10.1016/j.bbagen.2019.129440. Epub 2019 Sep 16. Biochim Biophys Acta Gen Subj. 2020. PMID: 31536751
217 results