Dokholyan NV - Search Results

1

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Nguyen PH, Ramamoorthy A, Sahoo BR, Zheng J, Faller P, Straub JE, Dominguez L, Shea JE, Dokholyan NV, De Simone A, Ma B, Nussinov R, Najafi S, Ngo ST, Loquet A, Chiricotto M, Ganguly P, McCarty J, Li MS, Hall C, Wang Y, Miller Y, Melchionna S, Habenstein B, Timr S, Chen J, Hnath B, Strodel B, Kayed R, Lesné S, Wei G, Sterpone F, Doig AJ, Derreumaux P. Nguyen PH, et al. Among authors: dokholyan nv. Chem Rev. 2021 Feb 24;121(4):2545-2647. doi: 10.1021/acs.chemrev.0c01122. Epub 2021 Feb 5. Chem Rev. 2021. PMID: 33543942 Free PMC article. Review.

2

Folding of Cu, Zn superoxide dismutase and familial amyotrophic lateral sclerosis.

Khare SD, Ding F, Dokholyan NV. Khare SD, et al. Among authors: dokholyan nv. J Mol Biol. 2003 Nov 28;334(3):515-25. doi: 10.1016/j.jmb.2003.09.069. J Mol Biol. 2003. PMID: 14623191

3

Reconstruction of the src-SH3 protein domain transition state ensemble using multiscale molecular dynamics simulations.

Ding F, Guo W, Dokholyan NV, Shakhnovich EI, Shea JE. Ding F, et al. Among authors: dokholyan nv. J Mol Biol. 2005 Jul 29;350(5):1035-50. doi: 10.1016/j.jmb.2005.05.017. J Mol Biol. 2005. PMID: 15982666

4

Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants.

Khare SD, Dokholyan NV. Khare SD, et al. Among authors: dokholyan nv. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3147-52. doi: 10.1073/pnas.0511266103. Epub 2006 Feb 17. Proc Natl Acad Sci U S A. 2006. PMID: 16488975 Free PMC article.

5

The complex molecular biology of amyotrophic lateral sclerosis (ALS).

Redler RL, Dokholyan NV. Redler RL, et al. Among authors: dokholyan nv. Prog Mol Biol Transl Sci. 2012;107:215-62. doi: 10.1016/B978-0-12-385883-2.00002-3. Prog Mol Biol Transl Sci. 2012. PMID: 22482452 Free PMC article. Review.

6

Non-native soluble oligomers of Cu/Zn superoxide dismutase (SOD1) contain a conformational epitope linked to cytotoxicity in amyotrophic lateral sclerosis (ALS).

Redler RL, Fee L, Fay JM, Caplow M, Dokholyan NV. Redler RL, et al. Among authors: dokholyan nv. Biochemistry. 2014 Apr 15;53(14):2423-32. doi: 10.1021/bi500158w. Epub 2014 Apr 2. Biochemistry. 2014. PMID: 24660965 Free PMC article.

7

Controlling Allosteric Networks in Proteins.

Dokholyan NV. Dokholyan NV. Chem Rev. 2016 Jun 8;116(11):6463-87. doi: 10.1021/acs.chemrev.5b00544. Epub 2016 Feb 19. Chem Rev. 2016. PMID: 26894745 Review.

8

β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology.

Proctor EA, Mowrey DD, Dokholyan NV. Proctor EA, et al. Among authors: dokholyan nv. PLoS Comput Biol. 2019 Jul 19;15(7):e1007225. doi: 10.1371/journal.pcbi.1007225. eCollection 2019 Jul. PLoS Comput Biol. 2019. PMID: 31323035 Free PMC article.

9

SOD1 oligomers in amyotrophic lateral sclerosis.

Choi ES, Dokholyan NV. Choi ES, et al. Among authors: dokholyan nv. Curr Opin Struct Biol. 2021 Feb;66:225-230. doi: 10.1016/j.sbi.2020.12.002. Epub 2021 Jan 16. Curr Opin Struct Biol. 2021. PMID: 33465527 Free PMC article. Review.

10

Engineering an Allosteric Control of Protein Function.

Vishweshwaraiah YL, Chen J, Dokholyan NV. Vishweshwaraiah YL, et al. Among authors: dokholyan nv. J Phys Chem B. 2021 Feb 25;125(7):1806-1814. doi: 10.1021/acs.jpcb.0c11640. Epub 2021 Feb 10. J Phys Chem B. 2021. PMID: 33566608 Free PMC article. Review.

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