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Page 1
ERBB family fusions are recurrent and actionable oncogenic targets across cancer types.
Schubert L, Elliott A, Le AT, Estrada-Bernal A, Doebele RC, Lou E, Borghaei H, Demeure MJ, Kurzrock R, Reuss JE, Ou SI, Braxton DR, Thomas CA, Darabi S, Korn WM, El-Deiry WS, Liu SV. Schubert L, et al. Among authors: doebele rc. Front Oncol. 2023 Apr 24;13:1115405. doi: 10.3389/fonc.2023.1115405. eCollection 2023. Front Oncol. 2023. PMID: 37168365 Free PMC article.
Correlations between the percentage of tumor cells showing an anaplastic lymphoma kinase (ALK) gene rearrangement, ALK signal copy number, and response to crizotinib therapy in ALK fluorescence in situ hybridization-positive nonsmall cell lung cancer.
Camidge DR, Theodoro M, Maxson DA, Skokan M, O'Brien T, Lu X, Doebele RC, Barón AE, Varella-Garcia M. Camidge DR, et al. Among authors: doebele rc. Cancer. 2012 Sep 15;118(18):4486-94. doi: 10.1002/cncr.27411. Epub 2012 Jan 26. Cancer. 2012. PMID: 22282074 Free PMC article.
Targeting ALK, ROS1, and BRAF kinases.
Doebele RC, Camidge DR. Doebele RC, et al. J Thorac Oncol. 2012 Dec;7(16 Suppl 5):S375-6. doi: 10.1097/JTO.0b013e31826df05e. J Thorac Oncol. 2012. PMID: 23160323 Free PMC article. Review. No abstract available.
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR. Doebele RC, et al. Blood. 2009 Nov 12;114(20):4592-600. doi: 10.1182/blood-2009-04-217042. Epub 2009 Aug 26. Blood. 2009. PMID: 19710505 Free PMC article.
Biomarkers are here to stay for clinical research and standard care.
Bunn PA Jr, Hirsch FR, Doebele RC, Camidge DR, Varella-Garcia M, Franklin W. Bunn PA Jr, et al. Among authors: doebele rc. J Thorac Oncol. 2010 Aug;5(8):1113-5. doi: 10.1097/JTO.0b013e3181e7616e. J Thorac Oncol. 2010. PMID: 20661083 Free article. No abstract available.
Sunitinib combined with pemetrexed and cisplatin: results of a phase I dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma.
Camidge DR, Blais N, Jonker DJ, Soulières D, Doebele RC, Ruiz-Garcia A, Thall A, Zhang K, Laurie SA, Chao RC, Chow LQ. Camidge DR, et al. Among authors: doebele rc. Cancer Chemother Pharmacol. 2013 Feb;71(2):307-19. doi: 10.1007/s00280-012-2008-6. Epub 2012 Oct 30. Cancer Chemother Pharmacol. 2013. PMID: 23108697 Clinical Trial.
157 results