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Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.
Sandberg A, Luheshi LM, Söllvander S, Pereira de Barros T, Macao B, Knowles TP, Biverstål H, Lendel C, Ekholm-Petterson F, Dubnovitsky A, Lannfelt L, Dobson CM, Härd T. Sandberg A, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15595-600. doi: 10.1073/pnas.1001740107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713699 Free PMC article.
Observation of spatial propagation of amyloid assembly from single nuclei.
Knowles TP, White DA, Abate AR, Agresti JJ, Cohen SI, Sperling RA, De Genst EJ, Dobson CM, Weitz DA. Knowles TP, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14746-51. doi: 10.1073/pnas.1105555108. Epub 2011 Aug 26. Proc Natl Acad Sci U S A. 2011. PMID: 21876182 Free PMC article.
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.
Cohen SI, Linse S, Luheshi LM, Hellstrand E, White DA, Rajah L, Otzen DE, Vendruscolo M, Dobson CM, Knowles TP. Cohen SI, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9758-63. doi: 10.1073/pnas.1218402110. Epub 2013 May 23. Proc Natl Acad Sci U S A. 2013. PMID: 23703910 Free PMC article.
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.
Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M. Habchi J, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208. doi: 10.1073/pnas.1615613114. Epub 2016 Dec 23. Proc Natl Acad Sci U S A. 2017. PMID: 28011763 Free PMC article.
803 results