Dobo K - Search Results

1

Hasselgren C, Ahlberg E, Akahori Y, Amberg A, Anger LT, Atienzar F, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Cammerer Z, Cronin MTD, Crooks I, Cross KP, Custer L, Dobo K, Doktorova T, Faulkner D, Ford KA, Fortin MC, Frericks M, Gad-McDonald SE, Gellatly N, Gerets H, Gervais V, Glowienke S, Van Gompel J, Harvey JS, Hillegass J, Honma M, Hsieh JH, Hsu CW, Barton-Maclaren TS, Johnson C, Jolly R, Jones D, Kemper R, Kenyon MO, Kruhlak NL, Kulkarni SA, Kümmerer K, Leavitt P, Masten S, Miller S, Moudgal C, Muster W, Paulino A, Lo Piparo E, Powley M, Quigley DP, Reddy MV, Richarz AN, Schilter B, Snyder RD, Stavitskaya L, Stidl R, Szabo DT, Teasdale A, Tice RR, Trejo-Martin A, Vuorinen A, Wall BA, Watts P, White AT, Wichard J, Witt KL, Woolley A, Woolley D, Zwickl C, Myatt GJ. Hasselgren C, et al. Among authors: dobo k. Regul Toxicol Pharmacol. 2019 Oct;107:104403. doi: 10.1016/j.yrtph.2019.104403. Epub 2019 Jun 11. Regul Toxicol Pharmacol. 2019. PMID: 31195068 Free PMC article.

2

The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development.

Dobo KL, Greene N, Cyr MO, Caron S, Ku WW. Dobo KL, et al. Regul Toxicol Pharmacol. 2006 Apr;44(3):282-93. doi: 10.1016/j.yrtph.2006.01.004. Epub 2006 Feb 7. Regul Toxicol Pharmacol. 2006. PMID: 16464524

3

An evaluation of the sensitivity of the Ames assay to discern low-level mutagenic impurities.

Kenyon MO, Cheung JR, Dobo KL, Ku WW. Kenyon MO, et al. Regul Toxicol Pharmacol. 2007 Jun;48(1):75-86. doi: 10.1016/j.yrtph.2007.01.006. Epub 2007 Feb 4. Regul Toxicol Pharmacol. 2007. PMID: 17379368

4

A strategy for the risk assessment of human genotoxic metabolites.

Dobo KL, Obach RS, Luffer-Atlas D, Bercu JP. Dobo KL, et al. Chem Res Toxicol. 2009 Feb;22(2):348-56. doi: 10.1021/tx8004339. Chem Res Toxicol. 2009. PMID: 19170655

5

Overview of genotoxic impurities in pharmaceutical development.

Bercu JP, Dobo KL, Gocke E, McGovern TJ. Bercu JP, et al. Int J Toxicol. 2009 Nov-Dec;28(6):468-78. doi: 10.1177/1091581809349195. Int J Toxicol. 2009. PMID: 19966139 Review.

6

Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in rats.

Dobo KL, Fiedler RD, Gunther WC, Thiffeault CJ, Cammerer Z, Coffing SL, Shutsky T, Schuler M. Dobo KL, et al. Mutat Res. 2011 Oct 9;725(1-2):13-21. doi: 10.1016/j.mrgentox.2011.06.005. Epub 2011 Jun 24. Mutat Res. 2011. PMID: 21729764 Free PMC article.

7

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.

Cammerer Z, Bhalli JA, Cao X, Coffing SL, Dickinson D, Dobo KL, Dobrovolsky VN, Engel M, Fiedler RD, Gunther WC, Heflich RH, Pearce MG, Shaddock JG, Shutsky T, Thiffeault CJ, Schuler M. Cammerer Z, et al. Environ Mol Mutagen. 2011 Dec;52(9):721-30. doi: 10.1002/em.20686. Environ Mol Mutagen. 2011. PMID: 22167886

8

In silico methods combined with expert knowledge rule out mutagenic potential of pharmaceutical impurities: an industry survey.

Dobo KL, Greene N, Fred C, Glowienke S, Harvey JS, Hasselgren C, Jolly R, Kenyon MO, Munzner JB, Muster W, Neft R, Reddy MV, White AT, Weiner S. Dobo KL, et al. Regul Toxicol Pharmacol. 2012 Apr;62(3):449-55. doi: 10.1016/j.yrtph.2012.01.007. Epub 2012 Jan 31. Regul Toxicol Pharmacol. 2012. PMID: 22321701

9

Determination of compound-specific acceptable daily intakes for 11 mutagenic carcinogens used in pharmaceutical synthesis.

Ellis P, Kenyon M, Dobo K. Ellis P, et al. Among authors: dobo k. Regul Toxicol Pharmacol. 2013 Mar;65(2):201-13. doi: 10.1016/j.yrtph.2012.11.008. Epub 2012 Dec 7. Regul Toxicol Pharmacol. 2013. PMID: 23228434

10

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities.

Sutter A, Amberg A, Boyer S, Brigo A, Contrera JF, Custer LL, Dobo KL, Gervais V, Glowienke S, van Gompel J, Greene N, Muster W, Nicolette J, Reddy MV, Thybaud V, Vock E, White AT, Müller L. Sutter A, et al. Regul Toxicol Pharmacol. 2013 Oct;67(1):39-52. doi: 10.1016/j.yrtph.2013.05.001. Epub 2013 May 10. Regul Toxicol Pharmacol. 2013. PMID: 23669331

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