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MYC multimers shield stalled replication forks from RNA polymerase.
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Solvie D, et al. Among authors: dobbelstein m. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23. Nature. 2022. PMID: 36424410
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.
Herold S, Kalb J, Büchel G, Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C, Dobbelstein M, Wolf E, Molenaar J, Versteeg R, Walz S, Eilers M. Herold S, et al. Among authors: dobbelstein m. Nature. 2019 Mar;567(7749):545-549. doi: 10.1038/s41586-019-1030-9. Epub 2019 Mar 20. Nature. 2019. PMID: 30894746 Free PMC article.
Mdm4 supports DNA replication in a p53-independent fashion.
Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M. Wohlberedt K, et al. Among authors: dobbelstein m. Oncogene. 2020 Jun;39(25):4828-4843. doi: 10.1038/s41388-020-1325-1. Epub 2020 May 19. Oncogene. 2020. PMID: 32427989 Free PMC article.
Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma.
Roeschert I, Poon E, Henssen AG, Garcia HD, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G, Eilers M. Roeschert I, et al. Among authors: dobbelstein m. Nat Cancer. 2021 Mar;2(3):312-326. doi: 10.1038/s43018-020-00171-8. Epub 2021 Feb 11. Nat Cancer. 2021. PMID: 33768209 Free PMC article.
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. Papadopoulos D, et al. Among authors: dobbelstein m. Mol Cell. 2022 Jan 6;82(1):159-176.e12. doi: 10.1016/j.molcel.2021.11.002. Epub 2021 Nov 29. Mol Cell. 2022. PMID: 34847357 Free article.
MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression.
Giansanti C, Manzini V, Dickmanns A, Dickmanns A, Palumbieri MD, Sanchi A, Kienle SM, Rieth S, Scheffner M, Lopes M, Dobbelstein M. Giansanti C, et al. Among authors: dobbelstein m. Cell Rep. 2022 May 31;39(9):110879. doi: 10.1016/j.celrep.2022.110879. Cell Rep. 2022. PMID: 35649362 Free article.
p53 Activity Results in DNA Replication Fork Processivity.
Klusmann I, Rodewald S, Müller L, Friedrich M, Wienken M, Li Y, Schulz-Heddergott R, Dobbelstein M. Klusmann I, et al. Among authors: dobbelstein m. Cell Rep. 2016 Nov 8;17(7):1845-1857. doi: 10.1016/j.celrep.2016.10.036. Cell Rep. 2016. PMID: 27829155 Free article.
128 results