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Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways.
Syu LJ, Zhao X, Zhang Y, Grachtchouk M, Demitrack E, Ermilov A, Wilbert DM, Zheng X, Kaatz A, Greenson JK, Gumucio DL, Merchant JL, di Magliano MP, Samuelson LC, Dlugosz AA. Syu LJ, et al. Among authors: dlugosz aa. Oncotarget. 2016 Mar 1;7(9):10255-70. doi: 10.18632/oncotarget.7182. Oncotarget. 2016. PMID: 26859571 Free PMC article.
Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.
Verhaegen ME, Harms PW, Van Goor JJ, Arche J, Patrick MT, Wilbert D, Zabawa H, Grachtchouk M, Liu CJ, Hu K, Kelly MC, Chen P, Saunders TL, Weidinger S, Syu LJ, Runge JS, Gudjonsson JE, Wong SY, Brownell I, Cieslik M, Udager AM, Chinnaiyan AM, Tsoi LC, Dlugosz AA. Verhaegen ME, et al. Among authors: dlugosz aa. J Clin Invest. 2022 Apr 1;132(7):e152069. doi: 10.1172/JCI152069. J Clin Invest. 2022. PMID: 35143422 Free PMC article.
Hedgehog signaling regulates sebaceous gland development.
Allen M, Grachtchouk M, Sheng H, Grachtchouk V, Wang A, Wei L, Liu J, Ramirez A, Metzger D, Chambon P, Jorcano J, Dlugosz AA. Allen M, et al. Among authors: dlugosz aa. Am J Pathol. 2003 Dec;163(6):2173-8. doi: 10.1016/S0002-9440(10)63574-2. Am J Pathol. 2003. PMID: 14633591 Free PMC article.
Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.
Michael LE, Westerman BA, Ermilov AN, Wang A, Ferris J, Liu J, Blom M, Ellison DW, van Lohuizen M, Dlugosz AA. Michael LE, et al. Among authors: dlugosz aa. Neoplasia. 2008 Dec;10(12):1343-9, 5p following 1349. doi: 10.1593/neo.81078. Neoplasia. 2008. PMID: 19048113 Free PMC article.
140 results