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The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
Haas DA, Bala K, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF. Haas DA, et al. PLoS Pathog. 2013;9(11):e1003737. doi: 10.1371/journal.ppat.1003737. Epub 2013 Nov 7. PLoS Pathog. 2013. PMID: 24244164 Free PMC article. Clinical Trial.
Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells.
Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF. Alkharsah KR, et al. J Virol. 2011 Oct;85(19):10375-88. doi: 10.1128/JVI.00226-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795355 Free PMC article.
83 results