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Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis.
Spiera R, Kuwana M, Khanna D, Hummers L, Frech TM, Stevens W, Matucci-Cerinic M, Kafaja S, Distler O, Jun JB, Levy Y, Leszcyzński P, Gordon J, Steen V, Lee EB, Jankowski T, Litinsky I, Chung L, Hsu V, Mayes M, Sandorfi N, Simms RW, Finzel S, de Vries-Bouwstra J, Constantine S, Dgetluck N, Dinh Q, Bloom BJ, Furst DE, White B, Denton CP; RESOLVE-1 Study Group. Spiera R, et al. Among authors: distler o. Arthritis Rheumatol. 2023 Sep;75(9):1608-1618. doi: 10.1002/art.42510. Epub 2023 Jun 15. Arthritis Rheumatol. 2023. PMID: 37098795 Free article. Clinical Trial.
Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.
Distler O, Del Rosso A, Giacomelli R, Cipriani P, Conforti ML, Guiducci S, Gay RE, Michel BA, Brühlmann P, Müller-Ladner U, Gay S, Matucci-Cerinic M. Distler O, et al. Arthritis Res. 2002;4(6):R11. doi: 10.1186/ar596. Epub 2002 Aug 30. Arthritis Res. 2002. PMID: 12453314 Free PMC article.
Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways.
Distler JH, Hagen C, Hirth A, Müller-Ladner U, Lorenz HM, del Rosso A, Michel BA, Gay RE, Nanagara R, Nishioka K, Matucci-Cerinic M, Kalden JR, Gay S, Distler O. Distler JH, et al. Among authors: distler o. Mol Pharmacol. 2004 Feb;65(2):389-99. doi: 10.1124/mol.65.2.389. Mol Pharmacol. 2004. PMID: 14742681
Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis.
Distler O, Distler JH, Scheid A, Acker T, Hirth A, Rethage J, Michel BA, Gay RE, Müller-Ladner U, Matucci-Cerinic M, Plate KH, Gassmann M, Gay S. Distler O, et al. Among authors: distler jh. Circ Res. 2004 Jul 9;95(1):109-16. doi: 10.1161/01.RES.0000134644.89917.96. Epub 2004 Jun 3. Circ Res. 2004. PMID: 15178641
Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis.
Distler JH, Jüngel A, Kowal-Bielecka O, Michel BA, Gay RE, Sprott H, Matucci-Cerinic M, Chilla M, Reich K, Kalden JR, Müller-Ladner U, Lorenz HM, Gay S, Distler O. Distler JH, et al. Among authors: distler o. Arthritis Rheum. 2005 Mar;52(3):856-64. doi: 10.1002/art.20883. Arthritis Rheum. 2005. PMID: 15751077 Free article.
636 results