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Cancer and virus leads by HTS, chemical design and SEA data mining.
Thepchatri P, Min J, Ganesh T, Du Y, Lewis I, Kurtkaya S, Prussia A, Li L, Sneed B, Plemper RK, Fu H, Liotta DC, Snyder JP, Dingledine R, Sun A. Thepchatri P, et al. Among authors: dingledine r. Curr Top Med Chem. 2009;9(13):1159-71. doi: 10.2174/156802609789753581. Curr Top Med Chem. 2009. PMID: 19807668 Free PMC article. Review.
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.
Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis G, Dingledine R, Liotta D, Snyder JP, Sun A. Ganesh T, et al. Among authors: dingledine r. Bioorg Med Chem. 2008 Jul 15;16(14):6903-10. doi: 10.1016/j.bmc.2008.05.047. Epub 2008 May 27. Bioorg Med Chem. 2008. PMID: 18571929 Free PMC article.
Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.
Jiang J, Ganesh T, Du Y, Thepchatri P, Rojas A, Lewis I, Kurtkaya S, Li L, Qui M, Serrano G, Shaw R, Sun A, Dingledine R. Jiang J, et al. Among authors: dingledine r. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2307-12. doi: 10.1073/pnas.0909310107. Epub 2010 Jan 14. Proc Natl Acad Sci U S A. 2010. PMID: 20080612 Free PMC article.
Lead optimization studies of cinnamic amide EP2 antagonists.
Ganesh T, Jiang J, Yang MS, Dingledine R. Ganesh T, et al. Among authors: dingledine r. J Med Chem. 2014 May 22;57(10):4173-84. doi: 10.1021/jm5000672. Epub 2014 May 5. J Med Chem. 2014. PMID: 24773616 Free PMC article.
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.
Tahirovic YA, Geballe M, Gruszecka-Kowalik E, Myers SJ, Lyuboslavsky P, Le P, French A, Irier H, Choi WB, Easterling K, Yuan H, Wilson LJ, Kotloski R, McNamara JO, Dingledine R, Liotta DC, Traynelis SF, Snyder JP. Tahirovic YA, et al. Among authors: dingledine r. J Med Chem. 2008 Sep 25;51(18):5506-21. doi: 10.1021/jm8002153. J Med Chem. 2008. PMID: 18800760 Free PMC article.
228 results