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Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.
van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L. van de Veerdonk FL, et al. Among authors: dinarello ca. J Clin Invest. 2022 Jan 18;132(2):e144983. doi: 10.1172/JCI144983. J Clin Invest. 2022. PMID: 34847078 Free PMC article.
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.
van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, van der Meer JW, Hao R, Kalabokis V, Dinarello CA. van de Veerdonk FL, et al. Among authors: dinarello ca. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3001-5. doi: 10.1073/pnas.1121534109. Epub 2012 Feb 6. Proc Natl Acad Sci U S A. 2012. PMID: 22315422 Free PMC article.
Neutrophil-mediated inhibition of proinflammatory cytokine responses.
Gresnigt MS, Joosten LA, Verschueren I, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL. Gresnigt MS, et al. Among authors: dinarello ca. J Immunol. 2012 Nov 15;189(10):4806-15. doi: 10.4049/jimmunol.1103551. Epub 2012 Oct 10. J Immunol. 2012. PMID: 23053514 Clinical Trial.
1,090 results