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Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity.
Anfray C, Mainini F, Digifico E, Maeda A, Sironi M, Erreni M, Anselmo A, Ummarino A, Gandoy S, Expósito F, Redrado M, Serrano D, Calvo A, Martens M, Bravo S, Mantovani A, Allavena P, Andón FT. Anfray C, et al. Among authors: digifico e. J Immunother Cancer. 2021 Sep;9(9):e002408. doi: 10.1136/jitc-2021-002408. J Immunother Cancer. 2021. PMID: 34531246 Free PMC article.
The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.
Liguori M, Digifico E, Vacchini A, Avigni R, Colombo FS, Borroni EM, Farina FM, Milanesi S, Castagna A, Mannarino L, Craparotta I, Marchini S, Erba E, Panini N, Tamborini M, Rimoldi V, Allavena P, Belgiovine C. Liguori M, et al. Among authors: digifico e. Cell Mol Immunol. 2021 Mar;18(3):711-722. doi: 10.1038/s41423-020-0501-0. Epub 2020 Jul 29. Cell Mol Immunol. 2021. PMID: 32728200 Free PMC article.
Macrophages and cancer stem cells: a malevolent alliance.
Allavena P, Digifico E, Belgiovine C. Allavena P, et al. Among authors: digifico e. Mol Med. 2021 Sep 28;27(1):121. doi: 10.1186/s10020-021-00383-3. Mol Med. 2021. PMID: 34583655 Free PMC article. Review.
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