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Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies.
J Immunother Cancer. 2023 Dec 11;11(12):e007502. doi: 10.1136/jitc-2023-007502.
J Immunother Cancer. 2023.
PMID: 38081778
Free PMC article.
Kinetic, imaging based assay to measure NK cell cytotoxicity against adherent cells.
Croom-Perez TJ, Robles-Carillo LD, Oyer JL, Dieffenthaller TA, Hasan MF, Copik AJ.
Croom-Perez TJ, et al. Among authors: dieffenthaller ta.
Methods Cell Biol. 2023;178:63-91. doi: 10.1016/bs.mcb.2022.07.012. Epub 2022 Sep 13.
Methods Cell Biol. 2023.
PMID: 37516529
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TIGIT Expression on Activated NK Cells Correlates with Greater Anti-Tumor Activity but Promotes Functional Decline upon Lung Cancer Exposure: Implications for Adoptive Cell Therapy and TIGIT-Targeted Therapies.
Hasan MF, Croom-Perez TJ, Oyer JL, Dieffenthaller TA, Robles-Carrillo LD, Eloriaga JE, Kumar S, Andersen BW, Copik AJ.
Hasan MF, et al. Among authors: dieffenthaller ta.
Cancers (Basel). 2023 May 11;15(10):2712. doi: 10.3390/cancers15102712.
Cancers (Basel). 2023.
PMID: 37345049
Free PMC article.
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Cryopreserved PM21-Particle-Expanded Natural Killer Cells Maintain Cytotoxicity and Effector Functions In Vitro and In Vivo.
Oyer JL, Croom-Perez TJ, Dieffenthaller TA, Robles-Carillo LD, Gitto SB, Altomare DA, Copik AJ.
Oyer JL, et al. Among authors: dieffenthaller ta.
Front Immunol. 2022 Apr 7;13:861681. doi: 10.3389/fimmu.2022.861681. eCollection 2022.
Front Immunol. 2022.
PMID: 35464440
Free PMC article.
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