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Pyrazinamide triggers degradation of its target aspartate decarboxylase.
Gopal P, Sarathy JP, Yee M, Ragunathan P, Shin J, Bhushan S, Zhu J, Akopian T, Kandror O, Lim TK, Gengenbacher M, Lin Q, Rubin EJ, Grüber G, Dick T. Gopal P, et al. Among authors: dick t. Nat Commun. 2020 Apr 3;11(1):1661. doi: 10.1038/s41467-020-15516-1. Nat Commun. 2020. PMID: 32245967 Free PMC article.
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WY, Patel V, Beer D, Walker JR, Duraiswamy J, Jiricek J, Keller TH, Chatterjee A, Tan MP, Ujjini M, Rao SP, Camacho L, Bifani P, Mak PA, Ma I, Barnes SW, Chen Z, Plouffe D, Thayalan P, Ng SH, Au M, Lee BH, Tan BH, Ravindran S, Nanjundappa M, Lin X, Goh A, Lakshminarayana SB, Shoen C, Cynamon M, Kreiswirth B, Dartois V, Peters EC, Glynne R, Brenner S, Dick T. Pethe K, et al. Among authors: dick t. Nat Commun. 2010 Aug 24;1(5):57. doi: 10.1038/ncomms1060. Nat Commun. 2010. PMID: 20975714 Free PMC article.
Variations of subunit {varepsilon} of the Mycobacterium tuberculosis F1Fo ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207.
Biukovic G, Basak S, Manimekalai MS, Rishikesan S, Roessle M, Dick T, Rao SP, Hunke C, Grüber G. Biukovic G, et al. Among authors: dick t. Antimicrob Agents Chemother. 2013 Jan;57(1):168-76. doi: 10.1128/AAC.01039-12. Epub 2012 Oct 22. Antimicrob Agents Chemother. 2013. PMID: 23089752 Free PMC article.
Antibacterial drug discovery: doing it right.
Gengenbacher M, Dick T. Gengenbacher M, et al. Among authors: dick t. Chem Biol. 2015 Jan 22;22(1):5-6. doi: 10.1016/j.chembiol.2014.12.005. Chem Biol. 2015. PMID: 25615950
983 results