Diaz JF - Search Results

1

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.

Ma Y, Josa-Prado F, Essif JN, Liu S, Li S, Lucena-Agell D, Chan PY, Goossens K, Hortigüela R, Matesanz R, Wang Y, Gago F, Wang H, Risinger A, Diaz JF, Fang WS. Ma Y, et al. Among authors: diaz jf. Eur J Med Chem. 2023 Nov 5;259:115668. doi: 10.1016/j.ejmech.2023.115668. Epub 2023 Jul 19. Eur J Med Chem. 2023. PMID: 37490800

2

Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.

Buey RM, Díaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou KC, Sasmal PK, Ritzén A, Namoto K. Buey RM, et al. Among authors: diaz jf. Chem Biol. 2004 Feb;11(2):225-36. doi: 10.1016/j.chembiol.2004.01.014. Chem Biol. 2004. PMID: 15123284

3

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF. Buey RM, et al. Among authors: diaz jf. Nat Chem Biol. 2007 Feb;3(2):117-25. doi: 10.1038/nchembio853. Epub 2007 Jan 7. Nat Chem Biol. 2007. PMID: 17206139 Free article.

4

Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.

Yang CG, Barasoain I, Li X, Matesanz R, Liu R, Sharom FJ, Yin DL, Díaz JF, Fang WS. Yang CG, et al. Among authors: diaz jf. ChemMedChem. 2007 May;2(5):691-701. doi: 10.1002/cmdc.200700002. ChemMedChem. 2007. PMID: 17385753

5

Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues.

Wang L, Alcaraz AA, Matesanz R, Yang CG, Barasoain I, Díaz JF, Li YZ, Snyder JP, Fang WS. Wang L, et al. Among authors: diaz jf. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3191-4. doi: 10.1016/j.bmcl.2007.03.026. Epub 2007 Mar 14. Bioorg Med Chem Lett. 2007. PMID: 17395465

6

Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

La Regina G, Edler MC, Brancale A, Kandil S, Coluccia A, Piscitelli F, Hamel E, De Martino G, Matesanz R, Díaz JF, Scovassi AI, Prosperi E, Lavecchia A, Novellino E, Artico M, Silvestri R. La Regina G, et al. Among authors: diaz jf. J Med Chem. 2007 Jun 14;50(12):2865-74. doi: 10.1021/jm061479u. Epub 2007 May 12. J Med Chem. 2007. PMID: 17497841

7

The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin.

Canales A, Matesanz R, Gardner NM, Andreu JM, Paterson I, Díaz JF, Jiménez-Barbero J. Canales A, et al. Among authors: diaz jf. Chemistry. 2008;14(25):7557-69. doi: 10.1002/chem.200800039. Chemistry. 2008. PMID: 18449868

8

Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.

Matesanz R, Barasoain I, Yang CG, Wang L, Li X, de Inés C, Coderch C, Gago F, Barbero JJ, Andreu JM, Fang WS, Díaz JF. Matesanz R, et al. Among authors: diaz jf. Chem Biol. 2008 Jun;15(6):573-85. doi: 10.1016/j.chembiol.2008.05.008. Chem Biol. 2008. PMID: 18559268

9

Synthesis and biological activities of high affinity taxane-based fluorescent probes.

Li X, Barasoain I, Matesanz R, Díaz JF, Fang WS. Li X, et al. Among authors: diaz jf. Bioorg Med Chem Lett. 2009 Feb 1;19(3):751-4. doi: 10.1016/j.bmcl.2008.12.018. Epub 2008 Dec 10. Bioorg Med Chem Lett. 2009. PMID: 19128972

10

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses.

Barasoain I, García-Carril AM, Matesanz R, Maccari G, Trigili C, Mori M, Shi JZ, Fang WS, Andreu JM, Botta M, Díaz JF. Barasoain I, et al. Among authors: diaz jf. Chem Biol. 2010 Mar 26;17(3):243-53. doi: 10.1016/j.chembiol.2010.02.006. Chem Biol. 2010. PMID: 20338516

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