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Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor.
Ferreira AP, Cassago A, Gonçalves Kde A, Dias MM, Adamoski D, Ascenção CF, Honorato RV, de Oliveira JF, Ferreira IM, Fornezari C, Bettini J, Oliveira PS, Paes Leme AF, Portugal RV, Ambrosio AL, Dias SM. Ferreira AP, et al. Among authors: dias sm, dias mm. J Biol Chem. 2013 Sep 27;288(39):28009-20. doi: 10.1074/jbc.M113.501346. Epub 2013 Aug 8. J Biol Chem. 2013. PMID: 23935106 Free PMC article.
Glutaminase Affects the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor γ (PPARγ) via Direct Interaction.
de Guzzi Cassago CA, Dias MM, Pinheiro MP, Pasquali CC, Bastos ACS, Islam Z, Consonni SR, de Oliveira JF, Gomes EM, Ascenção CFR, Honorato R, Pauletti BA, Indolfo NC, Filho HVR, de Oliveira PSL, Figueira ACM, Paes Leme AF, Ambrosio ALB, Dias SMG. de Guzzi Cassago CA, et al. Among authors: dias smg, dias mm. Biochemistry. 2018 Nov 6;57(44):6293-6307. doi: 10.1021/acs.biochem.8b00773. Epub 2018 Oct 18. Biochemistry. 2018. PMID: 30295466
GLS2 is protumorigenic in breast cancers.
Dias MM, Adamoski D, Dos Reis LM, Ascenção CFR, de Oliveira KRS, Mafra ACP, da Silva Bastos AC, Quintero M, de G Cassago C, Ferreira IM, Fidelis CHV, Rocco SA, Bajgelman MC, Stine Z, Berindan-Neagoe I, Calin GA, Ambrosio ALB, Dias SMG. Dias MM, et al. Among authors: dias smg. Oncogene. 2020 Jan;39(3):690-702. doi: 10.1038/s41388-019-1007-z. Epub 2019 Sep 20. Oncogene. 2020. PMID: 31541193
High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules.
E Costa RK, Rodrigues CT, H Campos JC, Paradela LS, Dias MM, Novaes da Silva B, de Valega Negrao CVZ, Gonçalves KA, Ascenção CFR, Adamoski D, Mercaldi GF, Bastos ACS, Batista FAH, Figueira AC, Cordeiro AT, Ambrosio ALB, Guido RVC, Dias SMG. E Costa RK, et al. Among authors: dias smg, dias mm. ACS Pharmacol Transl Sci. 2021 Dec 1;4(6):1849-1866. doi: 10.1021/acsptsci.1c00226. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927015 Free PMC article.
Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection.
Adamoski D, Dias MM, Quesñay JEN, Yang Z, Zagoriy I, Steyer AM, Rodrigues CT, da Silva Bastos AC, da Silva BN, Costa RKE, de Abreu FMO, Islam Z, Cassago A, van Heel MG, Consonni SR, Mattei S, Mahamid J, Portugal RV, Ambrosio ALB, Dias SMG. Adamoski D, et al. Among authors: dias mm. Nat Struct Mol Biol. 2023 Dec;30(12):1902-1912. doi: 10.1038/s41594-023-01118-0. Epub 2023 Oct 19. Nat Struct Mol Biol. 2023. PMID: 37857822
Exposure to progesterone before an ovulation synchronization protocol increases the follicular diameter and fertility of multiparous suckled Bos taurus cows.
Simões LMS, Lima EA, Carvalho LR, Martínez MBP, Zanatta GM, Santos MFO, Machado AB, Dias MM, Guerreiro BM, Freitas BG, Bastos MR, Sales JNS. Simões LMS, et al. Among authors: dias mm. Theriogenology. 2024 Apr 1;218:239-243. doi: 10.1016/j.theriogenology.2024.01.031. Epub 2024 Jan 26. Theriogenology. 2024. PMID: 38359562
172 results