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Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease.
de Oliveira Rezende Júnior C, Martinez PDG, Ferreira RAA, Koovits PJ, Miranda Soares B, Ferreira LLG, Michelan-Duarte S, Chelucci RC, Andricopulo AD, Matheeussen A, Van Pelt N, Caljon G, Maes L, Campbell S, Kratz JM, Mowbray CE, Dias LC. de Oliveira Rezende Júnior C, et al. Among authors: dias lc. Eur J Med Chem. 2023 Jan 15;246:114925. doi: 10.1016/j.ejmech.2022.114925. Epub 2022 Nov 15. Eur J Med Chem. 2023. PMID: 36459758 Free article.
Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity.
Massarico Serafim RA, Gonçalves JE, de Souza FP, de Melo Loureiro AP, Storpirtis S, Krogh R, Andricopulo AD, Dias LC, Ferreira EI. Massarico Serafim RA, et al. Among authors: dias lc. Eur J Med Chem. 2014 Jul 23;82:418-25. doi: 10.1016/j.ejmech.2014.05.077. Epub 2014 Jun 3. Eur J Med Chem. 2014. PMID: 24929292
Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans.
Krake SH, Martinez PDG, McLaren J, Ryan E, Chen G, White K, Charman SA, Campbell S, Willis P, Dias LC. Krake SH, et al. Among authors: dias lc. Eur J Med Chem. 2017 Jan 27;126:929-936. doi: 10.1016/j.ejmech.2016.12.024. Epub 2016 Dec 11. Eur J Med Chem. 2017. PMID: 28002775
2,3,8-Trisubstituted Quinolines with Antimalarial Activity.
Martinez PDG, Krake SH, Poggi ML, Campbell SF, Willis PA, Dias LC. Martinez PDG, et al. Among authors: dias lc. An Acad Bras Cienc. 2018 May 21;90(1 Suppl 2):1215-1231. doi: 10.1590/0001-3765201820170820. Print 2018. An Acad Bras Cienc. 2018. PMID: 29791525 Free article.
Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei.
Pereira GA, Santos LH, Wang SC, Martins LC, Villela FS, Liao W, Dessoy MA, Dias LC, Andricopulo AD, Costa MA, Nagem RA, Caffrey CR, Liedl KR, Caffarena ER, Ferreira RS. Pereira GA, et al. Among authors: dias lc. Future Med Chem. 2019 Jul;11(13):1537-1551. doi: 10.4155/fmc-2018-0523. Future Med Chem. 2019. PMID: 31469332 Free PMC article.
Synthetic Studies toward the Total Synthesis of Tautomycetin.
Pereira de Sant'Ana D, de Oliveira Rezende Júnior C, Campagne JM, Dias LC, Marcia de Figueiredo R. Pereira de Sant'Ana D, et al. Among authors: dias lc. J Org Chem. 2019 Oct 4;84(19):12344-12357. doi: 10.1021/acs.joc.9b01712. Epub 2019 Sep 16. J Org Chem. 2019. PMID: 31480837
149 results