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A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens.
Yan J, Nielsen TB, Lu P, Talyansky Y, Slarve M, Reza H, Novakovic B, Netea MG, Keller AE, Warren T, DiGiandomenico A, Sellman BR, Luna BM, Spellberg B. Yan J, et al. Among authors: digiandomenico a. Sci Transl Med. 2023 Oct 4;15(716):eadf9556. doi: 10.1126/scitranslmed.adf9556. Epub 2023 Oct 4. Sci Transl Med. 2023. PMID: 37792959 Free PMC article.
Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening.
DiGiandomenico A, Warrener P, Hamilton M, Guillard S, Ravn P, Minter R, Camara MM, Venkatraman V, Macgill RS, Lin J, Wang Q, Keller AE, Bonnell JC, Tomich M, Jermutus L, McCarthy MP, Melnick DA, Suzich JA, Stover CK. DiGiandomenico A, et al. J Exp Med. 2012 Jul 2;209(7):1273-87. doi: 10.1084/jem.20120033. Epub 2012 Jun 25. J Exp Med. 2012. PMID: 22734046 Free PMC article.
A novel anti-PcrV antibody providing enhanced protection against Pseudomonas aeruginosa in multiple animal infection models.
Warrener P, Varkey R, Bonnell JC, DiGiandomenico A, Camara M, Cook K, Peng L, Zha J, Chowdury P, Sellman B, Stover CK. Warrener P, et al. Among authors: digiandomenico a. Antimicrob Agents Chemother. 2014 Aug;58(8):4384-91. doi: 10.1128/AAC.02643-14. Epub 2014 May 19. Antimicrob Agents Chemother. 2014. PMID: 24841258 Free PMC article.
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.
DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK. DiGiandomenico A, et al. Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655. Sci Transl Med. 2014. PMID: 25391481
Antibacterial monoclonal antibodies: the next generation?
DiGiandomenico A, Sellman BR. DiGiandomenico A, et al. Curr Opin Microbiol. 2015 Oct;27:78-85. doi: 10.1016/j.mib.2015.07.014. Epub 2015 Aug 25. Curr Opin Microbiol. 2015. PMID: 26302478 Review.
Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide.
Thaden JT, Keller AE, Shire NJ, Camara MM, Otterson L, Huband M, Guenther CM, Zhao W, Warrener P, Stover CK, Fowler VG Jr, DiGiandomenico A. Thaden JT, et al. Among authors: digiandomenico a. J Infect Dis. 2016 Feb 15;213(4):640-8. doi: 10.1093/infdis/jiv436. Epub 2015 Sep 2. J Infect Dis. 2016. PMID: 26333940 Free PMC article.
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.
Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR. Cohen TS, et al. Among authors: digiandomenico a. Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922. Sci Transl Med. 2016. PMID: 26962155
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model.
Patel A, DiGiandomenico A, Keller AE, Smith TRF, Park DH, Ramos S, Schultheis K, Elliott STC, Mendoza J, Broderick KE, Wise MC, Yan J, Jiang J, Flingai S, Khan AS, Muthumani K, Humeau L, Cheng LI, Wachter-Rosati L, Stover CK, Sardesai NY, Weiner DB. Patel A, et al. Among authors: digiandomenico a. Nat Commun. 2017 Sep 21;8(1):637. doi: 10.1038/s41467-017-00576-7. Nat Commun. 2017. PMID: 28935938 Free PMC article.
MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model.
Le HN, Quetz JS, Tran VG, Le VTM, Aguiar-Alves F, Pinheiro MG, Cheng L, Yu L, Sellman BR, Stover CK, DiGiandomenico A, Diep BA. Le HN, et al. Among authors: digiandomenico a. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02565-17. doi: 10.1128/AAC.02565-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29483116 Free PMC article.
57 results