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Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial.
Chastre J, François B, Bourgeois M, Komnos A, Ferrer R, Rahav G, De Schryver N, Lepape A, Koksal I, Luyt CE, Sánchez-García M, Torres A, Eggimann P, Koulenti D, Holland TL, Ali O, Shoemaker K, Ren P, Sauser J, Ruzin A, Tabor DE, Akhgar A, Wu Y, Jiang Y, DiGiandomenico A, Colbert S, Vandamme D, Coenjaerts F, Malhotra-Kumar S, Timbermont L, Oliver A, Barraud O, Bellamy T, Bonten M, Goossens H, Reisner C, Esser MT, Jafri HS; COMBACTE-MAGNET EVADE Study Group. Chastre J, et al. Among authors: digiandomenico a. Crit Care. 2022 Nov 15;26(1):355. doi: 10.1186/s13054-022-04204-9. Crit Care. 2022. PMID: 36380312 Free PMC article. Clinical Trial.
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.
DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK. DiGiandomenico A, et al. Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655. Sci Transl Med. 2014. PMID: 25391481
MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model.
Le HN, Quetz JS, Tran VG, Le VTM, Aguiar-Alves F, Pinheiro MG, Cheng L, Yu L, Sellman BR, Stover CK, DiGiandomenico A, Diep BA. Le HN, et al. Among authors: digiandomenico a. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02565-17. doi: 10.1128/AAC.02565-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29483116 Free PMC article.
Phase 1 study of MEDI3902, an investigational anti-Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults.
Ali SO, Yu XQ, Robbie GJ, Wu Y, Shoemaker K, Yu L, DiGiandomenico A, Keller AE, Anude C, Hernandez-Illas M, Bellamy T, Falloon J, Dubovsky F, Jafri HS. Ali SO, et al. Among authors: digiandomenico a. Clin Microbiol Infect. 2019 May;25(5):629.e1-629.e6. doi: 10.1016/j.cmi.2018.08.004. Epub 2018 Aug 11. Clin Microbiol Infect. 2019. PMID: 30107283 Free article. Clinical Trial.
Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models.
Le HN, Tran VG, Vu TTT, Gras E, Le VTM, Pinheiro MG, Aguiar-Alves F, Schneider-Smith E, Carter HC, Sellman BR, Stover CK, DiGiandomenico A, Diep BA. Le HN, et al. Among authors: digiandomenico a. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00710-19. doi: 10.1128/AAC.00710-19. Print 2019 Aug. Antimicrob Agents Chemother. 2019. PMID: 31160288 Free PMC article.
Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model.
Aguiar-Alves F, Le HN, Tran VG, Gras E, Vu TTT, Dong OX, Quetz JS, Cheng LI, Yu L, Sellman BR, Stover CK, DiGiandomenico A, Diep BA. Aguiar-Alves F, et al. Among authors: digiandomenico a. Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0202221. doi: 10.1128/AAC.02022-21. Epub 2021 Dec 13. Antimicrob Agents Chemother. 2022. PMID: 34902264 Free PMC article.
Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice.
Shaikh MOF, Schaefers MM, Merakou C, DiBlasi M, Bonney S, Liao T, Zurakowski D, Kehl M, Tabor DE, DiGiandomenico A, Priebe GP. Shaikh MOF, et al. Among authors: digiandomenico a. Infect Immun. 2022 Oct 20;90(10):e0020322. doi: 10.1128/iai.00203-22. Epub 2022 Sep 7. Infect Immun. 2022. PMID: 36069593 Free PMC article.
Development and validation of a rabbit model of Pseudomonas aeruginosa non-ventilated pneumonia for preclinical drug development.
Gras E, Vu TTT, Nguyen NTQ, Tran VG, Mao Y, Tran ND, Mai NH, Dong OX, Jung DH, Iorio NLPP, Povoa HCC, Pinheiro MG, Aguiar-Alves F, Weiss WJ, Zheng B, Cheng LI, Stover CK, Sellman BR, DiGiandomenico A, Gibault L, Valour F, Diep BA. Gras E, et al. Among authors: digiandomenico a. Front Cell Infect Microbiol. 2023 Dec 11;13:1297281. doi: 10.3389/fcimb.2023.1297281. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 38149013 Free PMC article.
57 results