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Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Nagai Y, Miyakawa N, Takuwa H, Hori Y, Oyama K, Ji B, Takahashi M, Huang XP, Slocum ST, DiBerto JF, Xiong Y, Urushihata T, Hirabayashi T, Fujimoto A, Mimura K, English JG, Liu J, Inoue KI, Kumata K, Seki C, Ono M, Shimojo M, Zhang MR, Tomita Y, Nakahara J, Suhara T, Takada M, Higuchi M, Jin J, Roth BL, Minamimoto T. Nagai Y, et al. Among authors: diberto jf. Nat Neurosci. 2020 Sep;23(9):1157-1167. doi: 10.1038/s41593-020-0661-3. Epub 2020 Jul 6. Nat Neurosci. 2020. PMID: 32632286
Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.
Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ. Robinson JE, et al. Among authors: diberto jf. Neuropsychopharmacology. 2015 Oct;40(11):2614-22. doi: 10.1038/npp.2015.109. Epub 2015 Apr 16. Neuropsychopharmacology. 2015. PMID: 25881115 Free PMC article.
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.
Vardy E, Robinson JE, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL. Vardy E, et al. Among authors: diberto jf. Neuron. 2015 May 20;86(4):936-946. doi: 10.1016/j.neuron.2015.03.065. Epub 2015 Apr 30. Neuron. 2015. PMID: 25937170 Free PMC article.
DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo.
Thompson KJ, Khajehali E, Bradley SJ, Navarrete JS, Huang XP, Slocum S, Jin J, Liu J, Xiong Y, Olsen RHJ, Diberto JF, Boyt KM, Pina MM, Pati D, Molloy C, Bundgaard C, Sexton PM, Kash TL, Krashes MJ, Christopoulos A, Roth BL, Tobin AB. Thompson KJ, et al. Among authors: diberto jf. ACS Pharmacol Transl Sci. 2018 Sep 14;1(1):61-72. doi: 10.1021/acsptsci.8b00012. Epub 2018 Jul 27. ACS Pharmacol Transl Sci. 2018. PMID: 30868140 Free PMC article.
Nanobody-enabled monitoring of kappa opioid receptor states.
Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, Wang S, Zhang S, Diberto JF, Sciaky N, Carroll FI, Steyaert J, Wacker D, Roth BL. Che T, et al. Among authors: diberto jf. Nat Commun. 2020 Mar 2;11(1):1145. doi: 10.1038/s41467-020-14889-7. Nat Commun. 2020. PMID: 32123179 Free PMC article.
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.
Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT. Olsen RHJ, et al. Among authors: diberto jf. Nat Chem Biol. 2020 Aug;16(8):841-849. doi: 10.1038/s41589-020-0535-8. Epub 2020 May 4. Nat Chem Biol. 2020. PMID: 32367019 Free PMC article.
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor.
Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL. Kim K, et al. Among authors: diberto jf. Cell. 2020 Sep 17;182(6):1574-1588.e19. doi: 10.1016/j.cell.2020.08.024. Cell. 2020. PMID: 32946782 Free PMC article.
The cranial windows of perception.
DiBerto JF, Roth BL. DiBerto JF, et al. Neuron. 2021 Aug 18;109(16):2499-2501. doi: 10.1016/j.neuron.2021.07.017. Neuron. 2021. PMID: 34411534 Free article.
Structure, function and pharmacology of human itch GPCRs.
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Among authors: diberto jf. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874 Free PMC article.
42 results