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Cotargeting of miR-126-3p and miR-221-3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signalling.
Di Paolo D, Pontis F, Moro M, Centonze G, Bertolini G, Milione M, Mensah M, Segale M, Petraroia I, Borzi C, Suatoni P, Brignole C, Perri P, Ponzoni M, Pastorino U, Sozzi G, Fortunato O. Di Paolo D, et al. Mol Oncol. 2021 Nov;15(11):2969-2988. doi: 10.1002/1878-0261.13036. Epub 2021 Jul 21. Mol Oncol. 2021. PMID: 34107168 Free PMC article.
MiR-486-5p Targets CD133+ Lung Cancer Stem Cells through the p85/AKT Pathway.
Moro M, Fortunato O, Bertolini G, Mensah M, Borzi C, Centonze G, Andriani F, Di Paolo D, Perri P, Ponzoni M, Pastorino U, Sozzi G, Boeri M. Moro M, et al. Among authors: di paolo d. Pharmaceuticals (Basel). 2022 Feb 28;15(3):297. doi: 10.3390/ph15030297. Pharmaceuticals (Basel). 2022. PMID: 35337095 Free PMC article.
Combined Replenishment of miR-34a and let-7b by Targeted Nanoparticles Inhibits Tumor Growth in Neuroblastoma Preclinical Models.
Di Paolo D, Pastorino F, Brignole C, Corrias MV, Emionite L, Cilli M, Tamma R, Priddy L, Amaro A, Ferrari D, Marotta R, Ferretti E, Pfeffer U, Ribatti D, Sementa AR, Brown D, Ikegaki N, Shimada H, Ponzoni M, Perri P. Di Paolo D, et al. Small. 2020 May;16(20):e1906426. doi: 10.1002/smll.201906426. Epub 2020 Apr 22. Small. 2020. PMID: 32323486
Therapeutic targeting of TLR9 inhibits cell growth and induces apoptosis in neuroblastoma.
Brignole C, Marimpietri D, Di Paolo D, Perri P, Morandi F, Pastorino F, Zorzoli A, Pagnan G, Loi M, Caffa I, Erminio G, Haupt R, Gambini C, Pistoia V, Ponzoni M. Brignole C, et al. Among authors: di paolo d. Cancer Res. 2010 Dec 1;70(23):9816-26. doi: 10.1158/0008-5472.CAN-10-1251. Epub 2010 Oct 8. Cancer Res. 2010. PMID: 20935225
Neuroblastoma-targeted nanoparticles entrapping siRNA specifically knockdown ALK.
Di Paolo D, Brignole C, Pastorino F, Carosio R, Zorzoli A, Rossi M, Loi M, Pagnan G, Emionite L, Cilli M, Bruno S, Chiarle R, Allen TM, Ponzoni M, Perri P. Di Paolo D, et al. Mol Ther. 2011 Jun;19(6):1131-40. doi: 10.1038/mt.2011.54. Epub 2011 Apr 12. Mol Ther. 2011. PMID: 21487394 Free PMC article.
Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma.
Di Paolo D, Ambrogio C, Pastorino F, Brignole C, Martinengo C, Carosio R, Loi M, Pagnan G, Emionite L, Cilli M, Ribatti D, Allen TM, Chiarle R, Ponzoni M, Perri P. Di Paolo D, et al. Mol Ther. 2011 Dec;19(12):2201-12. doi: 10.1038/mt.2011.142. Epub 2011 Aug 9. Mol Ther. 2011. PMID: 21829174 Free PMC article.
95 results