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AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
Morande PE, Yan XJ, Sepulveda J, Seija N, Marquez ME, Sotelo N, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P. Morande PE, et al. Among authors: di noia jm. Blood. 2021 Jul 22;138(3):246-258. doi: 10.1182/blood.2020008654. Blood. 2021. PMID: 34292322 Free article.
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination.
Zahn A, Eranki AK, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM. Zahn A, et al. Among authors: di noia jm. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E988-97. doi: 10.1073/pnas.1320486111. Epub 2014 Mar 3. Proc Natl Acad Sci U S A. 2014. PMID: 24591601 Free PMC article.
HSP90 inhibitors decrease AID levels and activity in mice and in human cells.
Montamat-Sicotte D, Litzler LC, Abreu C, Safavi S, Zahn A, Orthwein A, Müschen M, Oppezzo P, Muñoz DP, Di Noia JM. Montamat-Sicotte D, et al. Among authors: di noia jm. Eur J Immunol. 2015 Aug;45(8):2365-76. doi: 10.1002/eji.201545462. Epub 2015 May 18. Eur J Immunol. 2015. PMID: 25912253 Free PMC article.
Pharmacological manipulation of AID.
Methot SP, Di Noia JM. Methot SP, et al. Among authors: di noia jm. Oncotarget. 2015 Sep 29;6(29):26550-1. doi: 10.18632/oncotarget.5269. Oncotarget. 2015. PMID: 26337342 Free PMC article. No abstract available.
63 results