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MCL-1 is a prognostic indicator and drug target in breast cancer.
Campbell KJ, Dhayade S, Ferrari N, Sims AH, Johnson E, Mason SM, Dickson A, Ryan KM, Kalna G, Edwards J, Tait SWG, Blyth K. Campbell KJ, et al. Among authors: dhayade s. Cell Death Dis. 2018 Jan 16;9(2):19. doi: 10.1038/s41419-017-0035-2. Cell Death Dis. 2018. PMID: 29339815 Free PMC article.
Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function.
Campbell KJ, Mason SM, Winder ML, Willemsen RBE, Cloix C, Lawson H, Rooney N, Dhayade S, Sims AH, Blyth K, Tait SWG. Campbell KJ, et al. Among authors: dhayade s. Cell Death Differ. 2021 Sep;28(9):2589-2600. doi: 10.1038/s41418-021-00773-4. Epub 2021 Mar 31. Cell Death Differ. 2021. PMID: 33785871 Free PMC article.
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proïcs E, Rubio-Patiño C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG. Giampazolias E, et al. Among authors: dhayade s. Nat Cell Biol. 2017 Sep;19(9):1116-1129. doi: 10.1038/ncb3596. Epub 2017 Aug 28. Nat Cell Biol. 2017. PMID: 28846096 Free PMC article.
Formate induces a metabolic switch in nucleotide and energy metabolism.
Oizel K, Tait-Mulder J, Fernandez-de-Cossio-Diaz J, Pietzke M, Brunton H, Lilla S, Dhayade S, Athineos D, Blanco GR, Sumpton D, Mackay GM, Blyth K, Zanivan SR, Meiser J, Vazquez A. Oizel K, et al. Among authors: dhayade s. Cell Death Dis. 2020 May 4;11(5):310. doi: 10.1038/s41419-020-2523-z. Cell Death Dis. 2020. PMID: 32366892 Free PMC article.
A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing.
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A, Dhayade S, Athineos D, Caley M, Mannella V, Blyth K, Inman GJ, Leigh IM. Hassan S, et al. Among authors: dhayade s. Int J Mol Sci. 2019 Jul 12;20(14):3428. doi: 10.3390/ijms20143428. Int J Mol Sci. 2019. PMID: 31336867 Free PMC article.
Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.
Humpton TJ, Nomura K, Weber J, Magnussen HM, Hock AK, Nixon C, Dhayade S, Stevenson D, Huang DT, Strathdee D, Blyth K, Vousden KH. Humpton TJ, et al. Among authors: dhayade s. Genes Dev. 2021 Jan 1;35(1-2):117-132. doi: 10.1101/gad.341875.120. Epub 2020 Dec 17. Genes Dev. 2021. PMID: 33334825 Free PMC article.
Increased formate overflow is a hallmark of oxidative cancer.
Meiser J, Schuster A, Pietzke M, Vande Voorde J, Athineos D, Oizel K, Burgos-Barragan G, Wit N, Dhayade S, Morton JP, Dornier E, Sumpton D, Mackay GM, Blyth K, Patel KJ, Niclou SP, Vazquez A. Meiser J, et al. Among authors: dhayade s. Nat Commun. 2018 Apr 10;9(1):1368. doi: 10.1038/s41467-018-03777-w. Nat Commun. 2018. PMID: 29636461 Free PMC article.
21 results