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Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones.
Shchekotikhin AE, Glazunova VA, Dezhenkova LG, Luzikov YN, Sinkevich YB, Kovalenko LV, Buyanov VN, Balzarini J, Huang FC, Lin JJ, Huang HS, Shtil AA, Preobrazhenskaya MN. Shchekotikhin AE, et al. Among authors: dezhenkova lg. Bioorg Med Chem. 2009 Mar 1;17(5):1861-9. doi: 10.1016/j.bmc.2009.01.047. Epub 2009 Jan 27. Bioorg Med Chem. 2009. PMID: 19208482
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
Tevyashova AN, Olsufyeva EN, Turchin KF, Balzarini J, Bykov EE, Dezhenkova LG, Shtil AA, Preobrazhenskaya MN. Tevyashova AN, et al. Among authors: dezhenkova lg. Bioorg Med Chem. 2009 Jul 15;17(14):4961-7. doi: 10.1016/j.bmc.2009.05.076. Epub 2009 Jun 6. Bioorg Med Chem. 2009. PMID: 19535252
Novel antitumor L-arabinose derivative of indolocarbazole with high affinity to DNA.
Kaluzhny DN, Tatarskiy VV Jr, Dezhenkova LG, Plikhtyak IL, Miniker TD, Shchyolkina AK, Strel'tsov SA, Chilov GG, Novikov FN, Kubasova IY, Smirnova ZS, Mel'nik SY, Livshits MA, Borisova OF, Shtil AA. Kaluzhny DN, et al. Among authors: dezhenkova lg. ChemMedChem. 2009 Oct;4(10):1641-8. doi: 10.1002/cmdc.200900227. ChemMedChem. 2009. PMID: 19672918
Modification of olivomycin A at the side chain of the aglycon yields the derivative with perspective antitumor characteristics.
Tevyashova AN, Shtil AA, Olsufyeva EN, Luzikov YN, Reznikova MI, Dezhenkova LG, Isakova EB, Bukhman VM, Durandin NA, Vinogradov AM, Kuzmin VA, Preobrazhenskaya MN. Tevyashova AN, et al. Among authors: dezhenkova lg. Bioorg Med Chem. 2011 Dec 15;19(24):7387-93. doi: 10.1016/j.bmc.2011.10.055. Epub 2011 Oct 25. Bioorg Med Chem. 2011. PMID: 22088308
Role of the acyl groups in carbohydrate chains in cytotoxic properties of olivomycin A.
Tevyashova AN, Durandin NA, Vinogradov AM, Zbarsky VB, Reznikova MI, Dezhenkova LG, Bykov EE, Olsufyeva EN, Kuzmin VA, Shtil AA, Preobrazhenskaya MN. Tevyashova AN, et al. Among authors: dezhenkova lg. J Antibiot (Tokyo). 2013 Sep;66(9):523-30. doi: 10.1038/ja.2013.39. Epub 2013 May 22. J Antibiot (Tokyo). 2013. PMID: 23695417
46 results