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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Hagenbeek TJ, Zbieg JR, Hafner M, Mroue R, Lacap JA, Sodir NM, Noland CL, Afghani S, Kishore A, Bhat KP, Yao X, Schmidt S, Clausen S, Steffek M, Lee W, Beroza P, Martin S, Lin E, Fong R, Di Lello P, Kubala MH, Yang MN, Lau JT, Chan E, Arrazate A, An L, Levy E, Lorenzo MN, Lee HJ, Pham TH, Modrusan Z, Zang R, Chen YC, Kabza M, Ahmed M, Li J, Chang MT, Maddalo D, Evangelista M, Ye X, Crawford JJ, Dey A. Hagenbeek TJ, et al. Among authors: dey a. Nat Cancer. 2023 Jun;4(6):812-828. doi: 10.1038/s43018-023-00577-0. Epub 2023 Jun 5. Nat Cancer. 2023. PMID: 37277530 Free PMC article.
Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.
Arenzana TL, Lianoglou S, Seki A, Eidenschenk C, Cheung T, Seshasayee D, Hagenbeek T, Sambandam A, Noubade R, Peng I, Lesch J, DeVoss J, Wu X, Lee WP, Caplazi P, Webster J, Liu J, Pham VC, Arnott D, Lill JR, Modrusan Z, Dey A, Rutz S. Arenzana TL, et al. Among authors: dey a. Sci Immunol. 2018 Apr 20;3(22):eaal1953. doi: 10.1126/sciimmunol.aal1953. Sci Immunol. 2018. PMID: 29678836
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E, Shain A, Xu M, Lill J, Dixit VM, Bastian BC, Dey A. Webster JD, et al. Among authors: dey a. Pigment Cell Melanoma Res. 2019 Mar;32(2):269-279. doi: 10.1111/pcmr.12735. Epub 2018 Sep 24. Pigment Cell Melanoma Res. 2019. PMID: 30156010
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.
Hagenbeek TJ, Webster JD, Kljavin NM, Chang MT, Pham T, Lee HJ, Klijn C, Cai AG, Totpal K, Ravishankar B, Yang N, Lee DH, Walsh KB, Hatzivassiliou G, de la Cruz CC, Gould SE, Wu X, Lee WP, Yang S, Zhang Z, Gu Q, Ji Q, Jackson EL, Lim DS, Dey A. Hagenbeek TJ, et al. Among authors: dey a. Sci Signal. 2018 Sep 11;11(547):eaaj1757. doi: 10.1126/scisignal.aaj1757. Sci Signal. 2018. PMID: 30206136
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
Lee HJ, Pham T, Chang MT, Barnes D, Cai AG, Noubade R, Totpal K, Chen X, Tran C, Hagenbeek T, Wu X, Eastham-Anderson J, Tao J, Lee W, Bastian BC, Carbone M, Webster JD, Dey A. Lee HJ, et al. Among authors: dey a. Cancer Res. 2020 Apr 15;80(8):1656-1668. doi: 10.1158/0008-5472.CAN-19-1704. Epub 2020 Jan 27. Cancer Res. 2020. PMID: 31988076
The Hippo Pathway as a Driver of Select Human Cancers.
Kulkarni A, Chang MT, Vissers JHA, Dey A, Harvey KF. Kulkarni A, et al. Among authors: dey a. Trends Cancer. 2020 Sep;6(9):781-796. doi: 10.1016/j.trecan.2020.04.004. Epub 2020 May 20. Trends Cancer. 2020. PMID: 32446746 Review.
2,081 results