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3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.
Tourteau A, Andrzejak V, Body-Malapel M, Lemaire L, Lemoine A, Mansouri R, Djouina M, Renault N, El Bakali J, Desreumaux P, Muccioli GG, Lambert DM, Chavatte P, Rigo B, Leleu-Chavain N, Millet R. Tourteau A, et al. Among authors: desreumaux p. Bioorg Med Chem. 2013 Sep 1;21(17):5383-94. doi: 10.1016/j.bmc.2013.06.010. Epub 2013 Jun 15. Bioorg Med Chem. 2013. PMID: 23849204
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
El Bakali J, Gilleron P, Body-Malapel M, Mansouri R, Muccioli GG, Djouina M, Barczyk A, Klupsch F, Andrzejak V, Lipka E, Furman C, Lambert DM, Chavatte P, Desreumaux P, Millet R. El Bakali J, et al. Among authors: desreumaux p. J Med Chem. 2012 Oct 25;55(20):8948-52. doi: 10.1021/jm3008568. Epub 2012 Oct 12. J Med Chem. 2012. PMID: 23017078
Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.
Tourteau A, Leleu-Chavain N, Body-Malapel M, Andrzejak V, Barczyk A, Djouina M, Rigo B, Desreumaux P, Chavatte P, Millet R. Tourteau A, et al. Among authors: desreumaux p. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1322-6. doi: 10.1016/j.bmcl.2014.01.056. Epub 2014 Jan 28. Bioorg Med Chem Lett. 2014. PMID: 24508127
Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.
El Bakali J, Muccioli GG, Body-Malapel M, Djouina M, Klupsch F, Ghinet A, Barczyk A, Renault N, Chavatte P, Desreumaux P, Lambert DM, Millet R. El Bakali J, et al. Among authors: desreumaux p. ACS Med Chem Lett. 2014 Dec 4;6(2):198-203. doi: 10.1021/ml500439x. eCollection 2015 Feb 12. ACS Med Chem Lett. 2014. PMID: 25699149 Free PMC article.
280 results