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PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease.
Moreno-Fernandez ME, Giles DA, Oates JR, Chan CC, Damen MSMA, Doll JR, Stankiewicz TE, Chen X, Chetal K, Karns R, Weirauch MT, Romick-Rosendale L, Xanthakos SA, Sheridan R, Szabo S, Shah AS, Helmrath MA, Inge TH, Deshmukh H, Salomonis N, Divanovic S. Moreno-Fernandez ME, et al. Among authors: deshmukh h. Cell Metab. 2021 Jun 1;33(6):1187-1204.e9. doi: 10.1016/j.cmet.2021.04.018. Epub 2021 May 17. Cell Metab. 2021. PMID: 34004162 Free PMC article.
The Promise and Peril of Natural Killer Cell Therapies in Pulmonary Infection.
Rajaram S, Canaday LM, Ochayon DE, Rangel KM, Ali A, Gyurova IE, Krishnamurthy D, Fletcher JS, Reighard SD, Cox A, Weirauch MT, Kottyan LC, Deshmukh H, Zacharias WJ, Borchers MT, Waggoner SN. Rajaram S, et al. Among authors: deshmukh h. Immunity. 2020 Jun 16;52(6):887-889. doi: 10.1016/j.immuni.2020.04.018. Epub 2020 May 13. Immunity. 2020. PMID: 32405233 Free PMC article. No abstract available.
A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation.
Jackson CM, Demmert M, Mukherjee S, Isaacs T, Thompson R, Chastain C, Gray J, Senthamaraikannan P, Presicce P, Chetal K, Salomonis N, Miller LA, Jobe AH, Kallapur SG, Zacharias WJ, Lewkowich IP, Deshmukh H, Chougnet CA. Jackson CM, et al. Among authors: deshmukh h. Mucosal Immunol. 2022 Apr;15(4):730-744. doi: 10.1038/s41385-022-00495-x. Epub 2022 Mar 21. Mucosal Immunol. 2022. PMID: 35314757 Free PMC article.
Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates.
Toth A, Steinmeyer S, Kannan P, Gray J, Jackson CM, Mukherjee S, Demmert M, Sheak JR, Benson D, Kitzmiller J, Wayman JA, Presicce P, Cates C, Rubin R, Chetal K, Du Y, Miao Y, Gu M, Guo M, Kalinichenko VV, Kallapur SG, Miraldi ER, Xu Y, Swarr D, Lewkowich I, Salomonis N, Miller L, Sucre JS, Whitsett JA, Chougnet CA, Jobe AH, Deshmukh H, Zacharias WJ. Toth A, et al. Among authors: deshmukh h. Sci Transl Med. 2022 Mar 30;14(638):eabl8574. doi: 10.1126/scitranslmed.abl8574. Epub 2022 Mar 30. Sci Transl Med. 2022. PMID: 35353543 Free PMC article.
The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota.
Stevens J, Steinmeyer S, Bonfield M, Peterson L, Wang T, Gray J, Lewkowich I, Xu Y, Du Y, Guo M, Wynn JL, Zacharias W, Salomonis N, Miller L, Chougnet C, O'Connor DH, Deshmukh H. Stevens J, et al. Among authors: deshmukh h. Sci Transl Med. 2022 Jun 15;14(649):eabl3981. doi: 10.1126/scitranslmed.abl3981. Epub 2022 Jun 15. Sci Transl Med. 2022. PMID: 35704600 Free PMC article.
A census of the lung: CellCards from LungMAP.
Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Masso-Silva JA, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE; NHLBI LungMAP Consortium. Sun X, et al. Among authors: deshmukh h. Dev Cell. 2022 Jan 10;57(1):112-145.e2. doi: 10.1016/j.devcel.2021.11.007. Epub 2021 Dec 21. Dev Cell. 2022. PMID: 34936882 Free PMC article.
Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma.
Kim D, McAlees JW, Bischoff LJ, Kaur D, Houshel LK, Gray J, Hargis J, Davis X, Dudas PL, Deshmukh H, Lewkowich IP. Kim D, et al. Among authors: deshmukh h. Clin Exp Allergy. 2019 Mar;49(3):317-330. doi: 10.1111/cea.13301. Epub 2018 Nov 29. Clin Exp Allergy. 2019. PMID: 30353972 Free PMC article.
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice.
Wilburn AN, McAlees JW, Haslam DB, Graspeuntner S, Schmudde I, Laumonnier Y, Rupp J, Chougnet CA, Deshmukh H, Zacharias WJ, König P, Lewkowich IP. Wilburn AN, et al. Among authors: deshmukh h. Am J Respir Cell Mol Biol. 2023 May;68(5):498-510. doi: 10.1165/rcmb.2022-0367OC. Am J Respir Cell Mol Biol. 2023. PMID: 36622830 Free PMC article.
The role of metallothionein in the pathogenesis of acute lung injury.
Wesselkamper SC, McDowell SA, Medvedovic M, Dalton TP, Deshmukh HS, Sartor MA, Case LM, Henning LN, Borchers MT, Tomlinson CR, Prows DR, Leikauf GD. Wesselkamper SC, et al. Am J Respir Cell Mol Biol. 2006 Jan;34(1):73-82. doi: 10.1165/rcmb.2005-0248OC. Epub 2005 Sep 15. Am J Respir Cell Mol Biol. 2006. PMID: 16166738 Free PMC article.
228 results