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Whole-genome sequencing analysis of semi-supercentenarians.
Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, Iannuzzi V, Bacalini MG, Valsesia A, Carayol J, Raymond F, Ferrarini A, Xumerle L, Collino S, Mari D, Arosio B, Casati M, Ferri E, Monti D, Nacmias B, Sorbi S, Luiselli D, Pettener D, Castellani G, Sala C, Passarino G, De Rango F, D'Aquila P, Bertamini L, Martinelli N, Girelli D, Olivieri O, Giuliani C, Descombes P, Franceschi C. Garagnani P, et al. Among authors: descombes p. Elife. 2021 May 4;10:e57849. doi: 10.7554/eLife.57849. Elife. 2021. PMID: 33941312 Free PMC article.
Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring.
Horvath S, Pirazzini C, Bacalini MG, Gentilini D, Di Blasio AM, Delledonne M, Mari D, Arosio B, Monti D, Passarino G, De Rango F, D'Aquila P, Giuliani C, Marasco E, Collino S, Descombes P, Garagnani P, Franceschi C. Horvath S, et al. Among authors: descombes p. Aging (Albany NY). 2015 Dec;7(12):1159-70. doi: 10.18632/aging.100861. Aging (Albany NY). 2015. PMID: 26678252 Free PMC article.
Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans.
Sazzini M, Abondio P, Sarno S, Gnecchi-Ruscone GA, Ragno M, Giuliani C, De Fanti S, Ojeda-Granados C, Boattini A, Marquis J, Valsesia A, Carayol J, Raymond F, Pirazzini C, Marasco E, Ferrarini A, Xumerle L, Collino S, Mari D, Arosio B, Monti D, Passarino G, D'Aquila P, Pettener D, Luiselli D, Castellani G, Delledonne M, Descombes P, Franceschi C, Garagnani P. Sazzini M, et al. Among authors: descombes p. BMC Biol. 2020 May 22;18(1):51. doi: 10.1186/s12915-020-00778-4. BMC Biol. 2020. PMID: 32438927 Free PMC article.
The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms.
Garagnani P, Pirazzini C, Giuliani C, Candela M, Brigidi P, Sevini F, Luiselli D, Bacalini MG, Salvioli S, Capri M, Monti D, Mari D, Collino S, Delledonne M, Descombes P, Franceschi C. Garagnani P, et al. Among authors: descombes p. Biomed Res Int. 2014;2014:560340. doi: 10.1155/2014/560340. Epub 2014 Apr 24. Biomed Res Int. 2014. PMID: 24868529 Free PMC article. Review.
The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data.
Ferrarini A, Xumerle L, Griggio F, Garonzi M, Cantaloni C, Centomo C, Vargas SM, Descombes P, Marquis J, Collino S, Franceschi C, Garagnani P, Salisbury BA, Harvey JM, Delledonne M. Ferrarini A, et al. Among authors: descombes p. PLoS One. 2015 Jul 6;10(7):e0132180. doi: 10.1371/journal.pone.0132180. eCollection 2015. PLoS One. 2015. PMID: 26147798 Free PMC article.
Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.
Giuliani C, Pirazzini C, Delledonne M, Xumerle L, Descombes P, Marquis J, Mengozzi G, Monti D, Bellizzi D, Passarino G, Luiselli D, Franceschi C, Garagnani P. Giuliani C, et al. Among authors: descombes p. Mech Ageing Dev. 2017 Jul;165(Pt B):195-201. doi: 10.1016/j.mad.2017.02.007. Epub 2017 Feb 27. Mech Ageing Dev. 2017. PMID: 28242236 Review.
In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging.
Mashinchian O, Hong X, Michaud J, Migliavacca E, Lefebvre G, Boss C, De Franceschi F, Le Moal E, Collerette-Tremblay J, Isern J, Metairon S, Raymond F, Descombes P, Bouche N, Muñoz-Cánoves P, Feige JN, Bentzinger CF. Mashinchian O, et al. Among authors: descombes p. Elife. 2022 Mar 4;11:e57393. doi: 10.7554/eLife.57393. Elife. 2022. PMID: 35245177 Free PMC article.
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism.
Valsesia A, Wang QP, Gheldof N, Carayol J, Ruffieux H, Clark T, Shenton V, Oyston LJ, Lefebvre G, Metairon S, Chabert C, Walter O, Mironova P, Lau P, Descombes P, Viguerie N, Langin D, Harper ME, Astrup A, Saris WH, Dent R, Neely GG, Hager J. Valsesia A, et al. Among authors: descombes p. Nat Commun. 2019 Feb 1;10(1):540. doi: 10.1038/s41467-019-08492-8. Nat Commun. 2019. PMID: 30710084 Free PMC article.
Salivary α-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study.
Valsesia A, Kulkarni SS, Marquis J, Leone P, Mironova P, Walter O, Hjorth MF, Descombes P, Hager J, Saris WH, Astrup A, Darimont C, O'Callaghan NJ. Valsesia A, et al. Among authors: descombes p. Am J Clin Nutr. 2019 Apr 1;109(4):1029-1037. doi: 10.1093/ajcn/nqy363. Am J Clin Nutr. 2019. PMID: 30982860 Free article. Clinical Trial.
171 results