Desantis J - Search Results

1

Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance.

Nannetti G, Massari S, Mercorelli B, Bertagnin C, Desantis J, Palù G, Tabarrini O, Loregian A. Nannetti G, et al. Among authors: desantis j. Antiviral Res. 2019 May;165:55-64. doi: 10.1016/j.antiviral.2019.03.003. Epub 2019 Mar 15. Antiviral Res. 2019. PMID: 30885750

2

Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.

Palomba T, Tassone G, Vacca C, Bartalucci M, Valeri A, Pozzi C, Cross S, Siragusa L, Desantis J. Palomba T, et al. Among authors: desantis j. Int J Mol Sci. 2022 Nov 17;23(22):14218. doi: 10.3390/ijms232214218. Int J Mol Sci. 2022. PMID: 36430693 Free PMC article.

3

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.

Massari S, Nannetti G, Desantis J, Muratore G, Sabatini S, Manfroni G, Mercorelli B, Cecchetti V, Palù G, Cruciani G, Loregian A, Goracci L, Tabarrini O. Massari S, et al. Among authors: desantis j. J Med Chem. 2015 May 14;58(9):3830-42. doi: 10.1021/acs.jmedchem.5b00012. Epub 2015 Apr 20. J Med Chem. 2015. PMID: 25856229 Free article.

4

Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity.

Sancineto L, Mariotti A, Bagnoli L, Marini F, Desantis J, Iraci N, Santi C, Pannecouque C, Tabarrini O. Sancineto L, et al. Among authors: desantis j. J Med Chem. 2015 Dec 24;58(24):9601-14. doi: 10.1021/acs.jmedchem.5b01183. Epub 2015 Dec 10. J Med Chem. 2015. PMID: 26613134

5

Recent advances in the identification of Tat-mediated transactivation inhibitors: progressing toward a functional cure of HIV.

Tabarrini O, Desantis J, Massari S. Tabarrini O, et al. Among authors: desantis j. Future Med Chem. 2016;8(4):421-42. doi: 10.4155/fmc.16.3. Epub 2016 Mar 2. Future Med Chem. 2016. PMID: 26933891 Review.

6

Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors.

Corona A, Desantis J, Massari S, Distinto S, Masaoka T, Sabatini S, Esposito F, Manfroni G, Maccioni E, Cecchetti V, Pannecouque C, Le Grice SF, Tramontano E, Tabarrini O. Corona A, et al. Among authors: desantis j. ChemMedChem. 2016 Aug 19;11(16):1709-20. doi: 10.1002/cmdc.201600015. Epub 2016 Mar 16. ChemMedChem. 2016. PMID: 26990134 Free PMC article.

7

Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics.

Massari S, Goracci L, Desantis J, Tabarrini O. Massari S, et al. Among authors: desantis j. J Med Chem. 2016 Sep 8;59(17):7699-718. doi: 10.1021/acs.jmedchem.5b01474. Epub 2016 Apr 19. J Med Chem. 2016. PMID: 27046062 Review.

8

Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.

Desantis J, Nannetti G, Massari S, Barreca ML, Manfroni G, Cecchetti V, Palù G, Goracci L, Loregian A, Tabarrini O. Desantis J, et al. Eur J Med Chem. 2017 Sep 29;138:128-139. doi: 10.1016/j.ejmech.2017.06.015. Epub 2017 Jun 8. Eur J Med Chem. 2017. PMID: 28666191

9

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.

Massari S, Desantis J, Nannetti G, Sabatini S, Tortorella S, Goracci L, Cecchetti V, Loregian A, Tabarrini O. Massari S, et al. Among authors: desantis j. Org Biomol Chem. 2017 Sep 26;15(37):7944-7955. doi: 10.1039/c7ob02085f. Org Biomol Chem. 2017. PMID: 28902220

10

2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.

Nkizinkiko Y, Desantis J, Koivunen J, Haikarainen T, Murthy S, Sancineto L, Massari S, Ianni F, Obaji E, Loza MI, Pihlajaniemi T, Brea J, Tabarrini O, Lehtiö L. Nkizinkiko Y, et al. Among authors: desantis j. Sci Rep. 2018 Jan 26;8(1):1680. doi: 10.1038/s41598-018-19872-3. Sci Rep. 2018. PMID: 29374194 Free PMC article.

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