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Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.
Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, Evensen K, Lindberg B, Skagen K, Skjelland M, Singh P, Haug M, Ruseva MM, Kolev M, Bibby J, Marshall O, O'Brien B, Deeks N, Afzali B, Clark RJ, Woodruff TM, Pryor M, Yang ZH, Remaley AT, Mollnes TE, Hewitt SM, Yan B, Kazemian M, Kiss MG, Binder CJ, Halvorsen B, Espevik T, Kemper C. Niyonzima N, et al. Among authors: desai jv. Sci Immunol. 2021 Dec 24;6(66):eabf2489. doi: 10.1126/sciimmunol.abf2489. Epub 2021 Dec 24. Sci Immunol. 2021. PMID: 34932384 Free PMC article.
VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.
Break TJ, Desai JV, Healey KR, Natarajan M, Ferre EMN, Henderson C, Zelazny A, Siebenlist U, Yates CM, Cohen OJ, Schotzinger RJ, Perlin DS, Garvey EP, Lionakis MS. Break TJ, et al. Among authors: desai jv. J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094. doi: 10.1093/jac/dky170. J Antimicrob Chemother. 2018. PMID: 29788070 Free PMC article.
Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis.
Abusleme L, Diaz PI, Freeman AF, Greenwell-Wild T, Brenchley L, Desai JV, Ng WI, Holland SM, Lionakis MS, Segre JA, Kong HH, Moutsopoulos NM. Abusleme L, et al. Among authors: desai jv. JCI Insight. 2018 Sep 6;3(17):e122061. doi: 10.1172/jci.insight.122061. eCollection 2018 Sep 6. JCI Insight. 2018. PMID: 30185668 Free PMC article.
Inhibition of Bruton tyrosine kinase in patients with severe COVID-19.
Roschewski M, Lionakis MS, Sharman JP, Roswarski J, Goy A, Monticelli MA, Roshon M, Wrzesinski SH, Desai JV, Zarakas MA, Collen J, Rose K, Hamdy A, Izumi R, Wright GW, Chung KK, Baselga J, Staudt LM, Wilson WH. Roschewski M, et al. Among authors: desai jv. Sci Immunol. 2020 Jun 5;5(48):eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5. Sci Immunol. 2020. PMID: 32503877 Free PMC article.
56 results