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Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
J Med Chem. 2014 Mar 13;57(5):2013-32. doi: 10.1021/jm401836p. Epub 2014 Feb 12.
J Med Chem. 2014.
PMID: 24521299
The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.
Qiu D, Lemm JA, O'Boyle DR, Sun JH, Nower PT, Nguyen V, Hamann LG, Snyder LB, Deon DH, Ruediger E, Meanwell NA, Belema M, Gao M, Fridell RA.
Qiu D, et al. Among authors: deon dh.
J Gen Virol. 2011 Nov;92(Pt 11):2502-2511. doi: 10.1099/vir.0.034801-0. Epub 2011 Jul 27.
J Gen Virol. 2011.
PMID: 21795470
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Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier A.
Priestley ES, et al.
J Med Chem. 2022 Jul 14;65(13):8843-8854. doi: 10.1021/acs.jmedchem.2c00359. Epub 2022 Jun 21.
J Med Chem. 2022.
PMID: 35729784
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Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.
Beaulieu PL, Bolger G, Deon D, Duplessis M, Fazal G, Gagnon A, Garneau M, LaPlante S, Stammers T, Kukolj G, Duan J.
Beaulieu PL, et al.
Bioorg Med Chem Lett. 2015 Mar 1;25(5):1140-5. doi: 10.1016/j.bmcl.2014.12.078. Epub 2015 Jan 3.
Bioorg Med Chem Lett. 2015.
PMID: 25599836
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Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
Toulouse JL, Shi G, Lemay-St-Denis C, Ebert MCCJC, Deon D, Gagnon M, Ruediger E, Saint-Jacques K, Forge D, Vanden Eynde JJ, Marinier A, Ji X, Pelletier JN.
Toulouse JL, et al.
ACS Med Chem Lett. 2020 Sep 28;11(11):2261-2267. doi: 10.1021/acsmedchemlett.0c00393. eCollection 2020 Nov 12.
ACS Med Chem Lett. 2020.
PMID: 33214838
Free PMC article.
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Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN.
Toulouse JL, et al.
ACS Omega. 2019 Jun 10;4(6):10056-10069. doi: 10.1021/acsomega.9b00640. eCollection 2019 Jun 30.
ACS Omega. 2019.
PMID: 31460098
Free PMC article.
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Total synthesis of (+)-arteanniun M using the tandem oxy-Cope/ene reaction.
Barriault L, Deon DH.
Barriault L, et al. Among authors: deon dh.
Org Lett. 2001 Jun 14;3(12):1925-7. doi: 10.1021/ol015970l.
Org Lett. 2001.
PMID: 11405746
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