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Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.
Cancer Discov. 2023 Nov 1;13(11):2370-2393. doi: 10.1158/2159-8290.CD-23-0131.
Cancer Discov. 2023.
PMID: 37584601
Free PMC article.
MiR-592 activates the mTOR kinase, ERK1/ERK2 kinase signaling and imparts neuronal differentiation signature characteristic of Group 4 medulloblastoma.
Paul R, Bapat P, Deogharkar A, Kazi S, Singh SKV, Gupta T, Jalali R, Sridhar E, Moiyadi A, Shetty P, Shirsat NV.
Paul R, et al. Among authors: deogharkar a.
Hum Mol Genet. 2021 Nov 30;30(24):2524-2525. doi: 10.1093/hmg/ddab264.
Hum Mol Genet. 2021.
PMID: 34554250
No abstract available.
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MiR-592 activates the mTOR kinase, ERK1/ERK2 kinase signaling and imparts neuronal differentiation signature characteristic of Group 4 medulloblastoma.
Paul R, Bapat P, Deogharkar A, Kazi S, Singh SKV, Gupta T, Jalali R, Sridhar E, Moiyadi A, Shetty P, Shirsat NV.
Paul R, et al. Among authors: deogharkar a.
Hum Mol Genet. 2021 Nov 30;30(24):2416-2428. doi: 10.1093/hmg/ddab201.
Hum Mol Genet. 2021.
PMID: 34274968
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Downregulation of CRX, a Group 3-specific oncogenic transcription factor, inhibits TGF-β/activin signaling in medulloblastoma cells.
Masurkar SA, Deogharkar A, Bharambe HS, Shirsat NV.
Masurkar SA, et al. Among authors: deogharkar a.
Biochem Biophys Res Commun. 2021 Sep 3;568:76-82. doi: 10.1016/j.bbrc.2021.06.064. Epub 2021 Jun 27.
Biochem Biophys Res Commun. 2021.
PMID: 34192607
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Downregulation of ARID1B, a tumor suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways.
Deogharkar A, Singh SV, Bharambe HS, Paul R, Moiyadi A, Goel A, Shetty P, Sridhar E, Gupta T, Jalali R, Goel N, Gadewal N, Muthukumar S, Shirsat NV.
Deogharkar A, et al.
Hum Mol Genet. 2021 Aug 28;30(18):1721-1733. doi: 10.1093/hmg/ddab134.
Hum Mol Genet. 2021.
PMID: 33949667
Clinical Trial.
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Downregulation of miR-204 expression defines a highly aggressive subset of Group 3/Group 4 medulloblastomas.
Bharambe HS, Paul R, Panwalkar P, Jalali R, Sridhar E, Gupta T, Moiyadi A, Shetty P, Kazi S, Deogharkar A, Masurkar S, Yogi K, Kunder R, Gadewal N, Goel A, Goel N, Chinnaswamy G, Ramaswamy V, Shirsat NV.
Bharambe HS, et al. Among authors: deogharkar a.
Acta Neuropathol Commun. 2019 Apr 3;7(1):52. doi: 10.1186/s40478-019-0697-3.
Acta Neuropathol Commun. 2019.
PMID: 30944042
Free PMC article.
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Restoration of miR-30a expression inhibits growth, tumorigenicity of medulloblastoma cells accompanied by autophagy inhibition.
Singh SV, Dakhole AN, Deogharkar A, Kazi S, Kshirsagar R, Goel A, Moiyadi A, Jalali R, Sridhar E, Gupta T, Shetty P, Gadewal N, Shirsat NV.
Singh SV, et al. Among authors: deogharkar a.
Biochem Biophys Res Commun. 2017 Sep 30;491(4):946-952. doi: 10.1016/j.bbrc.2017.07.140. Epub 2017 Jul 27.
Biochem Biophys Res Commun. 2017.
PMID: 28757413
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