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Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models.
Sci Transl Med. 2022 Feb 9;14(631):eabh3763. doi: 10.1126/scitranslmed.abh3763. Epub 2022 Feb 9.
Sci Transl Med. 2022.
PMID: 35138910
Free PMC article.
Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.
Crouzier L, Denus M, Richard EM, Tavernier A, Diez C, Cubedo N, Maurice T, Delprat B.
Crouzier L, et al. Among authors: denus m.
Int J Mol Sci. 2021 Oct 13;22(20):11049. doi: 10.3390/ijms222011049.
Int J Mol Sci. 2021.
PMID: 34681705
Free PMC article.
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Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines.
Crouzier L, Richard EM, Diez C, Alzaeem H, Denus M, Cubedo N, Delaunay T, Glendenning E, Baxendale S, Liévens JC, Whitfield TT, Maurice T, Delprat B.
Crouzier L, et al. Among authors: denus m.
Hum Mol Genet. 2022 Aug 23;31(16):2711-2727. doi: 10.1093/hmg/ddac065.
Hum Mol Genet. 2022.
PMID: 35325133
Free PMC article.
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Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease.
Couly S, Denus M, Bouchet M, Rubinstenn G, Maurice T.
Couly S, et al. Among authors: denus m.
Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157. doi: 10.1093/ijnp/pyaa075.
Int J Neuropsychopharmacol. 2021.
PMID: 32977336
Free PMC article.
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Exposure of R6/2 mice in an enriched environment augments P42 therapy efficacy on Huntington's disease progression.
Couly S, Carles A, Denus M, Benigno-Anton L, Maschat F, Maurice T.
Couly S, et al. Among authors: denus m.
Neuropharmacology. 2021 Mar 15;186:108467. doi: 10.1016/j.neuropharm.2021.108467. Epub 2021 Jan 28.
Neuropharmacology. 2021.
PMID: 33516737
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Reg-1α, a New Substrate of Calpain-2 Depending on Its Glycosylation Status.
Lebart MC, Trousse F, Valette G, Torrent J, Denus M, Mestre-Frances N, Marcilhac A.
Lebart MC, et al. Among authors: denus m.
Int J Mol Sci. 2022 Aug 2;23(15):8591. doi: 10.3390/ijms23158591.
Int J Mol Sci. 2022.
PMID: 35955718
Free PMC article.
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[Unconventional protein secretion - new perspectives in protein trafficking].
Denus M, Fargues W, Filaquier A, Néel É, Marin P, Parmentier ML, Villeneuve J.
Denus M, et al.
Med Sci (Paris). 2024 Mar;40(3):267-274. doi: 10.1051/medsci/2024013. Epub 2024 Mar 22.
Med Sci (Paris). 2024.
PMID: 38520102
French.
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NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome.
Crouzier L, Richard EM, Diez C, Denus M, Peyrel A, Alzaeem H, Cubedo N, Delaunay T, Maurice T, Delprat B.
Crouzier L, et al. Among authors: denus m.
Mol Ther Methods Clin Dev. 2022 Oct 7;27:295-308. doi: 10.1016/j.omtm.2022.10.003. eCollection 2022 Dec 8.
Mol Ther Methods Clin Dev. 2022.
PMID: 36320410
Free PMC article.
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