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Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice.
Pak HH, Haws SA, Green CL, Koller M, Lavarias MT, Richardson NE, Yang SE, Dumas SN, Sonsalla M, Bray L, Johnson M, Barnes S, Darley-Usmar V, Zhang J, Yen CE, Denu JM, Lamming DW. Pak HH, et al. Among authors: denu jm. Nat Metab. 2021 Oct;3(10):1327-1341. doi: 10.1038/s42255-021-00466-9. Epub 2021 Oct 18. Nat Metab. 2021. PMID: 34663973 Free PMC article.
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Hebert AS, et al. Among authors: denu jm. Mol Cell. 2013 Jan 10;49(1):186-99. doi: 10.1016/j.molcel.2012.10.024. Epub 2012 Nov 29. Mol Cell. 2013. PMID: 23201123 Free PMC article.
Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.
Rhoads TW, Burhans MS, Chen VB, Hutchins PD, Rush MJP, Clark JP, Stark JL, McIlwain SJ, Eghbalnia HR, Pavelec DM, Ong IM, Denu JM, Markley JL, Coon JJ, Colman RJ, Anderson RM. Rhoads TW, et al. Among authors: denu jm. Cell Metab. 2018 Mar 6;27(3):677-688.e5. doi: 10.1016/j.cmet.2018.01.014. Cell Metab. 2018. PMID: 29514073 Free PMC article.
PGC-1a integrates a metabolism and growth network linked to caloric restriction.
Miller KN, Clark JP, Martin SA, Howell PR, Burhans MS, Haws SA, Johnson NB, Rhoads TW, Pavelec DM, Eliceiri KW, Roopra AS, Ntambi JM, Denu JM, Parks BW, Anderson RM. Miller KN, et al. Among authors: denu jm. Aging Cell. 2019 Oct;18(5):e12999. doi: 10.1111/acel.12999. Epub 2019 Jul 3. Aging Cell. 2019. PMID: 31267675 Free PMC article.
Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence.
Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM. Haws SA, et al. Among authors: denu jm. Mol Cell. 2020 Apr 16;78(2):210-223.e8. doi: 10.1016/j.molcel.2020.03.004. Epub 2020 Mar 23. Mol Cell. 2020. PMID: 32208170 Free PMC article.
Metabolism and the Epigenome: A Dynamic Relationship.
Haws SA, Leech CM, Denu JM. Haws SA, et al. Among authors: denu jm. Trends Biochem Sci. 2020 Sep;45(9):731-747. doi: 10.1016/j.tibs.2020.04.002. Epub 2020 May 6. Trends Biochem Sci. 2020. PMID: 32387193 Free PMC article. Review.
Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49th Annual Meeting of the American Aging Association.
Murphy ME, Narasimhan A, Adrian A, Kumar A, Green CL, Soto-Palma C, Henpita C, Camell C, Morrow CS, Yeh CY, Richardson CE, Hill CM, Moore DL, Lamming DW, McGregor ER, Simmons HA, Pak HH, Bai H, Denu JM, Clark J, Simcox J, Chittimalli K, Dahlquist K, Lee KA, Calubag M, Bouska M, Yousefzadeh MJ, Sonsalla M, Babygirija R, Yuan R, Tsuji T, Rhoads T, Menon V, Jarajapu YP, Zhu Y. Murphy ME, et al. Among authors: denu jm. Geroscience. 2022 Feb;44(1):39-52. doi: 10.1007/s11357-021-00479-y. Epub 2021 Oct 29. Geroscience. 2022. PMID: 34714522 Free PMC article. No abstract available.
204 results