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Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.
Raphemot R, Lonergan DF, Nguyen TT, Utley T, Lewis LM, Kadakia R, Weaver CD, Gogliotti R, Hopkins C, Lindsley CW, Denton JS. Raphemot R, et al. Among authors: denton js. Front Pharmacol. 2011 Nov 30;2:75. doi: 10.3389/fphar.2011.00075. eCollection 2011. Front Pharmacol. 2011. PMID: 22275899 Free PMC article.
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD. Kaufmann K, et al. Among authors: denton j. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86. doi: 10.1021/cn400062a. Epub 2013 Jun 13. ACS Chem Neurosci. 2013. PMID: 23730969 Free PMC article.
Direct activation of β-cell KATP channels with a novel xanthine derivative.
Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Raphemot R, et al. Among authors: denton js. Mol Pharmacol. 2014 Jun;85(6):858-65. doi: 10.1124/mol.114.091884. Epub 2014 Mar 19. Mol Pharmacol. 2014. PMID: 24646456 Free PMC article.
ROMK inhibitor actions in the nephron probed with diuretics.
Kharade SV, Flores D, Lindsley CW, Satlin LM, Denton JS. Kharade SV, et al. Among authors: denton js. Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F732-F737. doi: 10.1152/ajprenal.00423.2015. Epub 2015 Dec 9. Am J Physiol Renal Physiol. 2016. PMID: 26661652 Free PMC article.
112 results