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Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation.
Tonelli M, Catto M, Tasso B, Novelli F, Canu C, Iusco G, Pisani L, Stradis AD, Denora N, Sparatore A, Boido V, Carotti A, Sparatore F. Tonelli M, et al. Among authors: denora n. ChemMedChem. 2015 Jun;10(6):1040-53. doi: 10.1002/cmdc.201500104. Epub 2015 Apr 29. ChemMedChem. 2015. PMID: 25924599
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.
Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A. Farina R, et al. Among authors: denora n. J Med Chem. 2015 Jul 23;58(14):5561-78. doi: 10.1021/acs.jmedchem.5b00599. Epub 2015 Jul 9. J Med Chem. 2015. PMID: 26107513
Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif.
Pisani L, Farina R, Soto-Otero R, Denora N, Mangiatordi GF, Nicolotti O, Mendez-Alvarez E, Altomare CD, Catto M, Carotti A. Pisani L, et al. Among authors: denora n. Molecules. 2016 Mar 17;21(3):362. doi: 10.3390/molecules21030362. Molecules. 2016. PMID: 26999091 Free PMC article.
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.
Pisani L, Farina R, Catto M, Iacobazzi RM, Nicolotti O, Cellamare S, Mangiatordi GF, Denora N, Soto-Otero R, Siragusa L, Altomare CD, Carotti A. Pisani L, et al. Among authors: denora n. J Med Chem. 2016 Jul 28;59(14):6791-806. doi: 10.1021/acs.jmedchem.6b00562. Epub 2016 Jul 7. J Med Chem. 2016. PMID: 27347731
Pharmaceutical development of novel lactate-based 6-fluoro-l-DOPA formulations.
Denora N, Lopedota A, de Candia M, Cellamare S, Degennaro L, Luisi R, Mele A, Tricarico D, Cutrignelli A, Laquintana V, Altomare CD, Franco M, Dimiccoli V, Tolomeo A, Scilimati A. Denora N, et al. Eur J Pharm Sci. 2017 Mar 1;99:361-368. doi: 10.1016/j.ejps.2016.10.001. Epub 2016 Oct 4. Eur J Pharm Sci. 2017. PMID: 27717874
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats.
Cassano T, Lopalco A, de Candia M, Laquintana V, Lopedota A, Cutrignelli A, Perrone M, Iacobazzi RM, Bedse G, Franco M, Denora N, Altomare CD. Cassano T, et al. Among authors: denora n. Mol Pharm. 2017 Sep 5;14(9):3178-3187. doi: 10.1021/acs.molpharmaceut.7b00405. Epub 2017 Aug 22. Mol Pharm. 2017. PMID: 28780872
180 results