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Robust Strategy for Hit-to-Lead Discovery: NMR for SAR.
J Med Chem. 2023 Oct 12;66(19):13416-13427. doi: 10.1021/acs.jmedchem.3c00656. Epub 2023 Sep 21.
J Med Chem. 2023.
PMID: 37732695
Free PMC article.
Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities.
LaPlante SR, Roux V, Shahout F, LaPlante G, Woo S, Denk MM, Larda ST, Ayotte Y.
LaPlante SR, et al. Among authors: denk mm.
Nat Protoc. 2021 Nov;16(11):5250-5273. doi: 10.1038/s41596-021-00612-3. Epub 2021 Oct 27.
Nat Protoc. 2021.
PMID: 34707256
Review.
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Click-Functionalization of a Poly(Tetrazine-co-Fluorene)-Conjugated Polymer with a Series of trans-Cyclooctene Derivatives.
Kardelis V, Denk MM, Adronov A.
Kardelis V, et al. Among authors: denk mm.
Angew Chem Int Ed Engl. 2021 Feb 8;60(6):2980-2986. doi: 10.1002/anie.202010795. Epub 2020 Dec 1.
Angew Chem Int Ed Engl. 2021.
PMID: 33258541
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