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A conserved complex lipid signature marks human muscle aging and responds to short-term exercise.
Janssens GE, Molenaars M, Herzog K, Grevendonk L, Remie CME, Vervaart MAT, Elfrink HL, Wever EJM, Schomakers BV, Denis SW, Waterham HR, Pras-Raves ML, van Weeghel M, van Kampen AHC, Tammaro A, Butter LM, van der Rijt S, Florquin S, Jongejan A, Moerland PD, Hoeks J, Schrauwen P, Vaz FM, Houtkooper RH. Janssens GE, et al. Among authors: denis sw. Nat Aging. 2024 Apr 12. doi: 10.1038/s43587-024-00595-2. Online ahead of print. Nat Aging. 2024. PMID: 38609524
Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells.
Liang Z, Ralph-Epps T, Schmidtke MW, Lazcano P, Denis SW, Balážová M, Chakkour M, Hazime S, Ren M, Schlame M, Houtkooper RH, Greenberg ML. Liang Z, et al. Among authors: denis sw. bioRxiv [Preprint]. 2024 Feb 4:2024.02.03.578755. doi: 10.1101/2024.02.03.578755. bioRxiv. 2024. PMID: 38352304 Free PMC article. Preprint.
214 results