Dengler DG - Search Results

1

Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1.

Finneran D, Li Q, Subbarayan MS, Joly-Amado A, Kamath S, Dengler DG, Gordon MN, Jackson MR, Morgan D, Bickford PC, Smith LH, Nash KR. Finneran D, et al. Among authors: dengler dg. Glia. 2023 Feb;71(2):245-258. doi: 10.1002/glia.24269. Epub 2022 Sep 15. Glia. 2023. PMID: 36106533 Free PMC article.

2

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity.

Dengler DG, Sun Q, Harikumar KG, Miller LJ, Sergienko EA. Dengler DG, et al. SLAS Discov. 2022 Oct;27(7):384-394. doi: 10.1016/j.slasd.2022.07.001. Epub 2022 Jul 16. SLAS Discov. 2022. PMID: 35850480 Free PMC article.

3

Discovery of small molecule positive allosteric modulators of the secretin receptor.

Dengler DG, Harikumar KG, Pollari S, Sun Q, Brown BT, Shinoki-Iwaya A, Ardecky R, Miller LJ, Sergienko EA. Dengler DG, et al. Biochem Pharmacol. 2021 Mar;185:114451. doi: 10.1016/j.bcp.2021.114451. Epub 2021 Feb 3. Biochem Pharmacol. 2021. PMID: 33545115 Free PMC article.

4

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol.

Harikumar KG, Coudrat T, Desai AJ, Dong M, Dengler DG, Furness SGB, Christopoulos A, Wootten D, Sergienko EA, Sexton PM, Miller LJ. Harikumar KG, et al. Among authors: dengler dg. Front Endocrinol (Lausanne). 2021 Dec 7;12:789957. doi: 10.3389/fendo.2021.789957. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34950108 Free PMC article.

5

Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors.

Dengler DG, Sun Q, Holleran J, Pollari S, Beutel J, Brown BT, Shinoki Iwaya A, Ardecky R, Harikumar KG, Miller LJ, Sergienko EA. Dengler DG, et al. SLAS Discov. 2021 Jan;26(1):1-16. doi: 10.1177/2472555220945284. Epub 2020 Aug 4. SLAS Discov. 2021. PMID: 32749201 Free PMC article.

6

An allosteric modulator binds to a conformational hub in the β₂ adrenergic receptor.

Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. Liu X, et al. Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483378 Free PMC article.

7

Mechanism of Action and Structure-Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor.

Dengler DG, Harikumar KG, Yen A, Sergienko EA, Miller LJ. Dengler DG, et al. Membranes (Basel). 2023 Jan 24;13(2):150. doi: 10.3390/membranes13020150. Membranes (Basel). 2023. PMID: 36837653 Free PMC article.

8

Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for β-Arrestin-Biased D₂R Agonists.

Männel B, Dengler D, Shonberg J, Hübner H, Möller D, Gmeiner P. Männel B, et al. J Med Chem. 2017 Jun 8;60(11):4693-4713. doi: 10.1021/acs.jmedchem.7b00363. Epub 2017 May 18. J Med Chem. 2017. PMID: 28489379

9

Structure-based discovery of opioid analgesics with reduced side effects.

Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. Manglik A, et al. Nature. 2016 Sep 8;537(7619):185-190. doi: 10.1038/nature19112. Epub 2016 Aug 17. Nature. 2016. PMID: 27533032 Free PMC article.

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