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Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.
Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB. Yellaturu CR, et al. Among authors: deng x. J Biol Chem. 2009 Nov 13;284(46):31726-34. doi: 10.1074/jbc.M109.050914. Epub 2009 Sep 16. J Biol Chem. 2009. PMID: 19759400 Free PMC article.
Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.
Elam MB, Yellaturu C, Howell GE, Deng X, Cowan GS, Kumar P, Park EA, Hiler ML, Wilcox HG, Hughes TA, Cook GA, Raghow R. Elam MB, et al. Among authors: deng x. Metabolism. 2010 Apr;59(4):587-98. doi: 10.1016/j.metabol.2009.09.001. Epub 2009 Nov 14. Metabolism. 2010. PMID: 19913854 Free PMC article.
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