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Slc7a11 (xCT) protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in the corticosterone mouse model.
Demuyser T, Deneyer L, Bentea E, Albertini G, Femenia T, Walrave L, Sato H, Danbolt NC, De Bundel D, Michotte A, Lindskog M, Massie A, Smolders I. Demuyser T, et al. World J Biol Psychiatry. 2019 Jun;20(5):381-392. doi: 10.1080/15622975.2017.1371332. Epub 2017 Sep 27. World J Biol Psychiatry. 2019. PMID: 28882088
Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision.
Bentea E, Demuyser T, Van Liefferinge J, Albertini G, Deneyer L, Nys J, Merckx E, Michotte Y, Sato H, Arckens L, Massie A, Smolders I. Bentea E, et al. Among authors: demuyser t. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jun 3;59:49-58. doi: 10.1016/j.pnpbp.2015.01.010. Epub 2015 Jan 23. Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID: 25619129 Free article.
Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein.
Bentea E, Van der Perren A, Van Liefferinge J, El Arfani A, Albertini G, Demuyser T, Merckx E, Michotte Y, Smolders I, Baekelandt V, Massie A. Bentea E, et al. Among authors: demuyser t. Front Behav Neurosci. 2015 Mar 31;9:68. doi: 10.3389/fnbeh.2015.00068. eCollection 2015. Front Behav Neurosci. 2015. PMID: 25873870 Free PMC article.
Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.
Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin-Arbelet V, Holmseth S, Merckx E, Sato H, Aerts JL, Smolders I, Arckens L, Danbolt NC, Massie A. Van Liefferinge J, et al. Among authors: demuyser t. J Comp Neurol. 2016 Apr 1;524(5):1015-32. doi: 10.1002/cne.23889. Epub 2015 Oct 23. J Comp Neurol. 2016. PMID: 26494316
53 results