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Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
Shishodia S, Demetriades M, Zhang D, Tam NY, Maheswaran P, Clunie-O'Connor C, Tumber A, Leung IKH, Ng YM, Leissing TM, El-Sagheer AH, Salah E, Brown T, Aik WS, McDonough MA, Schofield CJ. Shishodia S, et al. Among authors: demetriades m. J Med Chem. 2021 Nov 25;64(22):16609-16625. doi: 10.1021/acs.jmedchem.1c01204. Epub 2021 Nov 11. J Med Chem. 2021. PMID: 34762429 Free PMC article.
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR. Karuppagounder SS, et al. Among authors: demetriades m. Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008. Sci Transl Med. 2016. PMID: 26936506 Free PMC article.
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, Ratcliffe PJ, Schofield CJ. Chan MC, et al. Among authors: demetriades m. PLoS One. 2015 Jul 6;10(7):e0132004. doi: 10.1371/journal.pone.0132004. eCollection 2015. PLoS One. 2015. PMID: 26147748 Free PMC article.
Pharmacological inhibition of FTO.
McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD. McMurray F, et al. Among authors: demetriades m. PLoS One. 2015 Apr 1;10(4):e0121829. doi: 10.1371/journal.pone.0121829. eCollection 2015. PLoS One. 2015. PMID: 25830347 Free PMC article.
On the histone lysine methyltransferase activity of fungal metabolite chaetocin.
Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA Jr, Brown R, Fuchter MJ. Cherblanc FL, et al. Among authors: demetriades m. J Med Chem. 2013 Nov 14;56(21):8616-25. doi: 10.1021/jm401063r. Epub 2013 Oct 25. J Med Chem. 2013. PMID: 24099080
Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
Valegård K, Iqbal A, Kershaw NJ, Ivison D, Généreux C, Dubus A, Blikstad C, Demetriades M, Hopkinson RJ, Lloyd AJ, Roper DI, Schofield CJ, Andersson I, McDonough MA. Valegård K, et al. Among authors: demetriades m. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1567-79. doi: 10.1107/S0907444913011013. Epub 2013 Jul 20. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23897479
24 results