Demars MD 2nd - Search Results

1

Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis.

DeMars MD 2nd, O'Connor SE. DeMars MD 2nd, et al. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2318586121. doi: 10.1073/pnas.2318586121. Epub 2024 Feb 6. Proc Natl Acad Sci U S A. 2024. PMID: 38319969 Free PMC article.

2

Recycling Upstream Redox Enzymes Expands the Regioselectivity of Cycloaddition in Pseudo-Aspidosperma Alkaloid Biosynthesis.

Kamileen MO, DeMars MD 2nd, Hong B, Nakamura Y, Paetz C, Lichman BR, Sonawane PD, Caputi L, O'Connor SE. Kamileen MO, et al. Among authors: demars md 2nd. J Am Chem Soc. 2022 Nov 2;144(43):19673-19679. doi: 10.1021/jacs.2c08107. Epub 2022 Oct 14. J Am Chem Soc. 2022. PMID: 36240425 Free PMC article.

3

Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.

Yang S, DeMars MD 2nd, Grandner JM, Olson NM, Anzai Y, Sherman DH, Houk KN. Yang S, et al. Among authors: demars md 2nd. J Am Chem Soc. 2020 Oct 21;142(42):17981-17988. doi: 10.1021/jacs.0c04388. Epub 2020 Oct 8. J Am Chem Soc. 2020. PMID: 33030347 Free PMC article.

4

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450.

DeMars MD 2nd, Samora NL, Yang S, Garcia-Borràs M, Sanders JN, Houk KN, Podust LM, Sherman DH. DeMars MD 2nd, et al. J Biol Chem. 2019 Nov 1;294(44):15947-15961. doi: 10.1074/jbc.RA119.010352. Epub 2019 Sep 5. J Biol Chem. 2019. PMID: 31488542 Free PMC article.

5

Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst.

Gilbert MM, DeMars MD 2nd, Yang S, Grandner JM, Wang S, Wang H, Narayan ARH, Sherman DH, Houk KN, Montgomery J. Gilbert MM, et al. Among authors: demars md 2nd. ACS Cent Sci. 2017 Dec 27;3(12):1304-1310. doi: 10.1021/acscentsci.7b00450. Epub 2017 Nov 15. ACS Cent Sci. 2017. PMID: 29296671 Free PMC article.

6

Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

Tay JH, Argüelles AJ, DeMars MD 2nd, Zimmerman PM, Sherman DH, Nagorny P. Tay JH, et al. Among authors: demars md 2nd. J Am Chem Soc. 2017 Jun 28;139(25):8570-8578. doi: 10.1021/jacs.7b03198. Epub 2017 Jun 19. J Am Chem Soc. 2017. PMID: 28627172 Free PMC article.

7

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

Lowell AN, DeMars MD 2nd, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH. Lowell AN, et al. Among authors: demars md 2nd. J Am Chem Soc. 2017 Jun 14;139(23):7913-7920. doi: 10.1021/jacs.7b02875. Epub 2017 Jun 5. J Am Chem Soc. 2017. PMID: 28525276 Free PMC article.

8

Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.

DeMars MD 2nd, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH. DeMars MD 2nd, et al. ACS Chem Biol. 2016 Sep 16;11(9):2642-54. doi: 10.1021/acschembio.6b00479. Epub 2016 Aug 5. ACS Chem Biol. 2016. PMID: 27420774 Free PMC article.

9

Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity.

Zhang K, Shafer BM, Demars MD 2nd, Stern HA, Fasan R. Zhang K, et al. Among authors: demars md 2nd. J Am Chem Soc. 2012 Nov 14;134(45):18695-704. doi: 10.1021/ja3073462. Epub 2012 Nov 2. J Am Chem Soc. 2012. PMID: 23121379 Free PMC article.

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