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Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.
Guenin-Macé L, Veyron-Churlet R, Thoulouze MI, Romet-Lemonne G, Hong H, Leadlay PF, Danckaert A, Ruf MT, Mostowy S, Zurzolo C, Bousso P, Chrétien F, Carlier MF, Demangel C. Guenin-Macé L, et al. Among authors: demangel c. J Clin Invest. 2013 Apr;123(4):1501-12. doi: 10.1172/JCI66576. Epub 2013 Mar 15. J Clin Invest. 2013. PMID: 23549080 Free PMC article.
Mycolactone subverts immunity by selectively blocking the Sec61 translocon.
Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C. Baron L, et al. Among authors: demangel c. J Exp Med. 2016 Dec 12;213(13):2885-2896. doi: 10.1084/jem.20160662. Epub 2016 Nov 7. J Exp Med. 2016. PMID: 27821549 Free PMC article.
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.
Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ. Zong G, et al. Among authors: demangel c. J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15. J Am Chem Soc. 2019. PMID: 31059257 Free PMC article.
Recombinant Antibodies against Mycolactone.
Naranjo L, Ferrara F, Blanchard N, Demangel C, D'Angelo S, Erasmus MF, Teixera AA, Bradbury ARM. Naranjo L, et al. Among authors: demangel c. Toxins (Basel). 2019 Jun 17;11(6):346. doi: 10.3390/toxins11060346. Toxins (Basel). 2019. PMID: 31212961 Free PMC article.
114 results