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The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval.
Tinaquero D, Crespo-García T, Utrilla RG, Nieto-Marín P, González-Guerra A, Rubio-Alarcón M, Cámara-Checa A, Dago M, Matamoros M, Pérez-Hernández M, Tamargo M, Cebrián J, Jalife J, Tamargo J, Bernal JA, Caballero R, Delpón E; ITACA Investigators. Tinaquero D, et al. Among authors: delpon e. Sci Rep. 2020 Jul 1;10(1):10707. doi: 10.1038/s41598-020-67109-z. Sci Rep. 2020. PMID: 32612162 Free PMC article.
Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration.
González de la Fuente M, Barana A, Gómez R, Amorós I, Dolz-Gaitón P, Sacristán S, Atienza F, Pita A, Pinto Á, Fernández-Avilés F, Caballero R, Tamargo J, Delpón E. González de la Fuente M, et al. Among authors: delpon e. Cardiovasc Res. 2013 Feb 1;97(2):379-88. doi: 10.1093/cvr/cvs313. Epub 2012 Oct 11. Cardiovasc Res. 2013. PMID: 23060133
Drug-induced atrial fibrillation: does it matter?
Tamargo J, Caballero R, Delpón E. Tamargo J, et al. Among authors: delpon e. Discov Med. 2012 Nov;14(78):295-9. Discov Med. 2012. PMID: 23200060 Free article. Review.
135 results