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Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Roth Flach RJ, Bollinger E, Reyes AR, Laforest B, Kormos BL, Liu S, Reese MR, Martinez Alsina LA, Buzon L, Zhang Y, Bechle B, Rosado A, Sahasrabudhe PV, Knafels J, Bhattacharya SK, Omoto K, Stansfield JC, Hurley LD, Song L, Luo L, Breitkopf SB, Monetti M, Cunio T, Tierney B, Geoly FJ, Delmore J, Siddall CP, Xue L, Yip KN, Kalgutkar AS, Miller RA, Zhang BB, Filipski KJ. Roth Flach RJ, et al. Among authors: delmore j. Nat Commun. 2023 Aug 9;14(1):4812. doi: 10.1038/s41467-023-40536-y. Nat Commun. 2023. PMID: 37558654 Free PMC article.
AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism.
Esquejo RM, Albuquerque B, Sher A, Blatnik M, Wald K, Peloquin M, Delmore J, Kindt E, Li W, Young JD, Cameron K, Miller RA. Esquejo RM, et al. Among authors: delmore j. Heliyon. 2022 Oct 14;8(10):e11091. doi: 10.1016/j.heliyon.2022.e11091. eCollection 2022 Oct. Heliyon. 2022. PMID: 36303906 Free PMC article.
Author Correction: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.
McMillin DW, Delmore J, Weisberg E, Negri JM, Geer CD, Klippel S, Mitsiades N, Schlossman RL, Munshi NC, Kung AL, Griffin JD, Richardson PG, Anderson KC, Mitsiades CS. McMillin DW, et al. Among authors: delmore j. Nat Med. 2024 Apr;30(4):1214. doi: 10.1038/s41591-024-02847-5. Nat Med. 2024. PMID: 38355975 No abstract available.
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Ryder TF, Calabrese MF, Walker GS, Cameron KO, Reyes AR, Borzilleri KA, Delmore J, Miller R, Kurumbail RG, Ward J, Kung DW, Brown JA, Edmonds DJ, Eng H, Wolford AC, Kalgutkar AS. Ryder TF, et al. Among authors: delmore j. J Med Chem. 2018 Aug 23;61(16):7273-7288. doi: 10.1021/acs.jmedchem.8b00807. Epub 2018 Aug 2. J Med Chem. 2018. PMID: 30036059
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
Esquejo RM, Salatto CT, Delmore J, Albuquerque B, Reyes A, Shi Y, Moccia R, Cokorinos E, Peloquin M, Monetti M, Barricklow J, Bollinger E, Smith BK, Day EA, Nguyen C, Geoghegan KF, Kreeger JM, Opsahl A, Ward J, Kalgutkar AS, Tess D, Butler L, Shirai N, Osborne TF, Steinberg GR, Birnbaum MJ, Cameron KO, Miller RA. Esquejo RM, et al. Among authors: delmore j. EBioMedicine. 2018 May;31:122-132. doi: 10.1016/j.ebiom.2018.04.009. Epub 2018 Apr 8. EBioMedicine. 2018. PMID: 29673898 Free PMC article.
Mass separator for radioactive isotopes.
Appelhans AD, Olson JE, Dahl DA, Ward MB, Robinson TA, Delmore JE. Appelhans AD, et al. Among authors: delmore je. J Radioanal Nucl Chem. 2018;315(2):207-209. doi: 10.1007/s10967-017-5649-4. Epub 2018 Jan 5. J Radioanal Nucl Chem. 2018. PMID: 29497225 Free PMC article.
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, Salatto CT, Coskran TM, Opsahl AC, Flynn D, Blatnik M, Li W, Kindt E, Foretz M, Viollet B, Ward J, Kurumbail RG, Kalgutkar AS, Wojtaszewski JFP, Cameron KO, Miller RA. Cokorinos EC, et al. Among authors: delmore j. Cell Metab. 2017 May 2;25(5):1147-1159.e10. doi: 10.1016/j.cmet.2017.04.010. Cell Metab. 2017. PMID: 28467931 Free article.
62 results