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Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Bateman RJ, Smith J, Donohue MC, Delmar P, Abbas R, Salloway S, Wojtowicz J, Blennow K, Bittner T, Black SE, Klein G, Boada M, Grimmer T, Tamaoka A, Perry RJ, Turner RS, Watson D, Woodward M, Thanasopoulou A, Lane C, Baudler M, Fox NC, Cummings JL, Fontoura P, Doody RS; GRADUATE I and II Investigators and the Gantenerumab Study Group. Bateman RJ, et al. Among authors: delmar p. N Engl J Med. 2023 Nov 16;389(20):1862-1876. doi: 10.1056/NEJMoa2304430. N Engl J Med. 2023. PMID: 37966285 Clinical Trial.
Comparing ARIA-E severity scales and effects of treatment management thresholds.
Klein G, Scelsi MA, Barakos J, Fiebach JB, Bracoud L, Suhy J, Delmar P, Lyons M, Wojtowicz J, Bullain S, Barkhof F, Purcell D. Klein G, et al. Among authors: delmar p. Alzheimers Dement (Amst). 2022 Dec 2;14(1):e12376. doi: 10.1002/dad2.12376. eCollection 2022. Alzheimers Dement (Amst). 2022. PMID: 36474747 Free PMC article.
Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease.
Wang G, Li Y, Xiong C, Benzinger TLS, Gordon BA, Hassenstab J, Aschenbrenner AJ, McDade E, Clifford DB, Libre-Guerra JJ, Shi X, Mummery CJ, van Dyck CH, Lah JJ, Honig LS, Day G, Ringman JM, Brooks WS, Fox NC, Suzuki K, Levin J, Jucker M, Delmar P, Bittner T, Bateman RJ; DIAN‐TU Study Team. Wang G, et al. Among authors: delmar p. Alzheimers Dement. 2024 Apr;20(4):2698-2706. doi: 10.1002/alz.13735. Epub 2024 Feb 23. Alzheimers Dement. 2024. PMID: 38400532 Free PMC article.
Evaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.
Wang G, Li Y, Xiong C, McDade E, Clifford DB, Mills SL, Santacruz AM, Aschenbrenner AJ, Hassenstab J, Benzinger TLS, Gordon BA, Fagan AM, Coalier KA, Libre-Guerra JJ, McCullough A, Joseph-Mathurin N, Chen CD, Mummery C, Wendelberger BA, Gauthier S, Masellis M, Holdridge KC, Yaari R, Chatterjee S, Sims J, Delmar P, Kerchner GA, Bittner T, Hofmann C, Bateman RJ; DIAN‐TU Study Team. Wang G, et al. Among authors: delmar p. Alzheimers Dement (Amst). 2022 Nov 3;14(1):e12367. doi: 10.1002/dad2.12367. eCollection 2022. Alzheimers Dement (Amst). 2022. PMID: 36348972 Free PMC article.
In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.
Aldea R, Grimm HP, Gieschke R, Hofmann C, Lott D, Bullain S, Delmar P, Klein G, Lyons M, Piazza F, Carare RO, Mazer NA. Aldea R, et al. Among authors: delmar p. Alzheimers Dement (N Y). 2022 Jun 6;8(1):e12306. doi: 10.1002/trc2.12306. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35676943 Free PMC article.
Standard and reference-based conditional mean imputation.
Wolbers M, Noci A, Delmar P, Gower-Page C, Yiu S, Bartlett JW. Wolbers M, et al. Among authors: delmar p. Pharm Stat. 2022 Nov;21(6):1246-1257. doi: 10.1002/pst.2234. Epub 2022 May 19. Pharm Stat. 2022. PMID: 35587109 Free PMC article.
Classification, Prediction, and Concordance of Cognitive and Functional Progression in Patients with Mild Cognitive Impairment in the United States: A Latent Class Analysis.
Mouchet J, Betts KA, Georgieva MV, Ionescu-Ittu R, Butler LM, Teitsma X, Delmar P, Kulalert T, Zhu J, Lema N, Desai U. Mouchet J, et al. Among authors: delmar p. J Alzheimers Dis. 2021;82(4):1667-1682. doi: 10.3233/JAD-210305. J Alzheimers Dis. 2021. PMID: 34219723 Free PMC article.
44 results