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Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation.
Nat Commun. 2023 Jul 13;14(1):4177. doi: 10.1038/s41467-023-39904-5.
Nat Commun. 2023.
PMID: 37443112
Free PMC article.
A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation.
Wurz RP, Dellamaggiore K, Dou H, Javier N, Lo MC, McCarter JD, Mohl D, Sastri C, Lipford JR, Cee VJ.
Wurz RP, et al. Among authors: dellamaggiore k.
J Med Chem. 2018 Jan 25;61(2):453-461. doi: 10.1021/acs.jmedchem.6b01781. Epub 2017 Apr 17.
J Med Chem. 2018.
PMID: 28378579
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Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases.
Luo X, Archibeque I, Dellamaggiore K, Smither K, Homann O, Lipford JR, Mohl D.
Luo X, et al. Among authors: dellamaggiore k.
iScience. 2022 Feb 26;25(3):103985. doi: 10.1016/j.isci.2022.103985. eCollection 2022 Mar 18.
iScience. 2022.
PMID: 35295813
Free PMC article.
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Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK).
Smith AL, Andrews KL, Beckmann H, Bellon SF, Beltran PJ, Booker S, Chen H, Chung YA, D'Angelo ND, Dao J, Dellamaggiore KR, Jaeckel P, Kendall R, Labitzke K, Long AM, Materna-Reichelt S, Mitchell P, Norman MH, Powers D, Rose M, Shaffer PL, Wu MM, Lipford JR.
Smith AL, et al. Among authors: dellamaggiore kr.
J Med Chem. 2015 Feb 12;58(3):1426-41. doi: 10.1021/jm5017494. Epub 2015 Jan 14.
J Med Chem. 2015.
PMID: 25587754
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Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.
Harrington PE, Biswas K, Malwitz D, Tasker AS, Mohr C, Andrews KL, Dellamaggiore K, Kendall R, Beckmann H, Jaeckel P, Materna-Reichelt S, Allen JR, Lipford JR.
Harrington PE, et al. Among authors: dellamaggiore k.
ACS Med Chem Lett. 2014 Sep 24;6(1):68-72. doi: 10.1021/ml500315b. eCollection 2015 Jan 8.
ACS Med Chem Lett. 2014.
PMID: 25589933
Free PMC article.
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Aptamer-based endocytosis of a lysosomal enzyme.
Chen CH, Dellamaggiore KR, Ouellette CP, Sedano CD, Lizadjohry M, Chernis GA, Gonzales M, Baltasar FE, Fan AL, Myerowitz R, Neufeld EF.
Chen CH, et al. Among authors: dellamaggiore kr.
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15908-13. doi: 10.1073/pnas.0808360105. Epub 2008 Oct 6.
Proc Natl Acad Sci U S A. 2008.
PMID: 18838694
Free PMC article.
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