Delemotte L - Search Results

1

A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction.

Clatot J, Currin CB, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte L, Vogels TP, Covarrubias M, Goldberg EM. Clatot J, et al. Among authors: delemotte l. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2307776121. doi: 10.1073/pnas.2307776121. Epub 2024 Jan 9. Proc Natl Acad Sci U S A. 2024. PMID: 38194456

2

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.

Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, Dürr KL. Chi G, et al. Among authors: delemotte l. Nat Commun. 2022 Jul 15;13(1):4087. doi: 10.1038/s41467-022-29594-w. Nat Commun. 2022. PMID: 35840580 Free PMC article.

3

Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na_v1.5.

Galleano I, Harms H, Choudhury K, Khoo K, Delemotte L, Pless SA. Galleano I, et al. Among authors: delemotte l. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2025320118. doi: 10.1073/pnas.2025320118. Proc Natl Acad Sci U S A. 2021. PMID: 34373326 Free PMC article.

4

Tracking the motion of the K_V1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy.

Pantazis A, Kaneko M, Angelini M, Steccanella F, Westerlund AM, Lindström SH, Nilsson M, Delemotte L, Saitta SC, Olcese R. Pantazis A, et al. Among authors: delemotte l. J Physiol. 2020 Nov;598(22):5245-5269. doi: 10.1113/JP280438. Epub 2020 Sep 21. J Physiol. 2020. PMID: 32833227 Free PMC article.

5

Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel.

Silverå Ejneby M, Gromova A, Ottosson NE, Borg S, Estrada-Mondragón A, Yazdi S, Apostolakis P, Elinder F, Delemotte L. Silverå Ejneby M, et al. Among authors: delemotte l. J Gen Physiol. 2021 Apr 5;153(4):e202012676. doi: 10.1085/jgp.202012676. J Gen Physiol. 2021. PMID: 33683319 Free PMC article.

6

Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism.

Frampton DJA, Choudhury K, Nikesjö J, Delemotte L, Liin SI. Frampton DJA, et al. Among authors: delemotte l. Elife. 2022 Jun 1;11:e77672. doi: 10.7554/eLife.77672. Elife. 2022. PMID: 35642964 Free PMC article.

7

Exploring the Viral Channel Kcv_PBCV-1 Function via Computation.

Andersson AEV, Kasimova MA, Delemotte L. Andersson AEV, et al. Among authors: delemotte l. J Membr Biol. 2018 Jun;251(3):419-430. doi: 10.1007/s00232-018-0022-2. Epub 2018 Feb 23. J Membr Biol. 2018. PMID: 29476260 Free PMC article.

8

Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA.

Delemotte L. Delemotte L. J Gen Physiol. 2018 Oct 1;150(10):1356-1359. doi: 10.1085/jgp.201812161. Epub 2018 Aug 24. J Gen Physiol. 2018. PMID: 30143551 Free PMC article.

9

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening.

Kang PW, Westerlund AM, Shi J, White KM, Dou AK, Cui AH, Silva JR, Delemotte L, Cui J. Kang PW, et al. Among authors: delemotte l. Sci Adv. 2020 Dec 11;6(50):eabd6798. doi: 10.1126/sciadv.abd6798. Print 2020 Dec. Sci Adv. 2020. PMID: 33310856 Free PMC article.

10

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine.

Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L. Choudhury K, et al. Among authors: delemotte l. Biophys J. 2022 Jan 4;121(1):11-22. doi: 10.1016/j.bpj.2021.12.010. Epub 2021 Dec 8. Biophys J. 2022. PMID: 34890580 Free PMC article.

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