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RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.
Van Eeckhoutte HP, Donovan C, Kim RY, Conlon TM, Ansari M, Khan H, Jayaraman R, Hansbro NG, Dondelinger Y, Delanghe T, Beal AM, Geddes B, Bertin J, Vanden Berghe T, De Volder J, Maes T, Vandenabeele P, Vanaudenaerde BM, Deforce D, Škevin S, Van Nieuwerburgh F, Verhamme FM, Joos GF, Idrees S, Schiller HB, Yildirim AÖ, Faiz A, Bertrand MJM, Brusselle GG, Hansbro PM, Bracke KR. Van Eeckhoutte HP, et al. Among authors: delanghe t. Eur Respir J. 2023 Apr 1;61(4):2201506. doi: 10.1183/13993003.01506-2022. Print 2023 Apr. Eur Respir J. 2023. PMID: 36549711
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM. Dondelinger Y, et al. Among authors: delanghe t. Nat Commun. 2019 Apr 15;10(1):1729. doi: 10.1038/s41467-019-09690-0. Nat Commun. 2019. PMID: 30988283 Free PMC article.
MK2 puts an additional brake on RIPK1 cytotoxic potential.
Dondelinger Y, Delanghe T, Bertrand MMJ. Dondelinger Y, et al. Among authors: delanghe t. Cell Death Differ. 2018 Mar;25(3):457-459. doi: 10.1038/s41418-017-0009-z. Epub 2018 Jan 9. Cell Death Differ. 2018. PMID: 29317761 Free PMC article. Review. No abstract available.
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.
Dondelinger Y, Delanghe T, Rojas-Rivera D, Priem D, Delvaeye T, Bruggeman I, Van Herreweghe F, Vandenabeele P, Bertrand MJM. Dondelinger Y, et al. Among authors: delanghe t. Nat Cell Biol. 2017 Oct;19(10):1237-1247. doi: 10.1038/ncb3608. Epub 2017 Sep 18. Nat Cell Biol. 2017. PMID: 28920952